Protein Info for ABZR86_RS17345 in Dyella japonica UNC79MFTsu3.2

Annotation: transcriptional regulator GcvA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 transmembrane" amino acids 100 to 114 (15 residues), see Phobius details PF00126: HTH_1" amino acids 13 to 71 (59 residues), 69.3 bits, see alignment E=2.1e-23 PF03466: LysR_substrate" amino acids 97 to 293 (197 residues), 113.6 bits, see alignment E=8.8e-37

Best Hits

KEGG orthology group: K03566, LysR family transcriptional regulator, glycine cleavage system transcriptional activator (inferred from 54% identity to mdi:METDI2350)

Predicted SEED Role

"Glycine cleavage system transcriptional activator GcvA" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JUV1 at UniProt or InterPro

Protein Sequence (296 amino acids)

>ABZR86_RS17345 transcriptional regulator GcvA (Dyella japonica UNC79MFTsu3.2)
MNSSVARRLPPLGALRAFEAAARHQSFRLAAEELSVTATAVSHQIRLLERLLGVALFERQ
VRKVVLTAEGRLLFPALRESFDLMAAAVAPLLRPKRRRILTVSATPAFVARLLVPRLAAF
QSRHPELDLRLHASTQPVDFAAQQIDAAIRYGKGPYRDLRNEPLLHTHFAPMCSPALKLR
TPKDLARHPLLHFQWQPSFREPPDWTAWRRAAGLRTLDIARGVTFSDETHAIDAAIAGQG
VALLNTALVADELARGTLVQPFGPMLDGLDYQLVYPLATENDPALAALREWLVHLD