Protein Info for ABZR86_RS16000 in Dyella japonica UNC79MFTsu3.2

Annotation: bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 661 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00149: Metallophos" amino acids 39 to 292 (254 residues), 30.6 bits, see alignment E=4.5e-11 PF02872: 5_nucleotid_C" amino acids 437 to 574 (138 residues), 72.4 bits, see alignment E=4.4e-24

Best Hits

KEGG orthology group: K01119, 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC: 3.1.4.16] (inferred from 50% identity to bvi:Bcep1808_2997)

Predicted SEED Role

"2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16)" in subsystem Purine conversions (EC 3.1.4.16)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.4.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JH53 at UniProt or InterPro

Protein Sequence (661 amino acids)

>ABZR86_RS16000 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (Dyella japonica UNC79MFTsu3.2)
MPLRHLPFAVLAAALLAGCASQSARTGRVPDGSHAQVAILETTDIHSNVLSYDYYKLKPD
ATVGYERTATLIRQARQQYPNSFLFDSGDTIQGSVLADYQAQVKPLGCNEELSIYAAMDA
VGYDGGTAGNHEFNYGLPFLSQVTGTPMNVDGGRSDRCAGPHFPLVLANVFSARDGAPIF
KPWAVVEKSIQVDTPGGGKRSVPLRVGIIGFTPPPILEWDKQNLEGKVTVTGVVEAAKKY
LPELQAQHPDLIVAVLHGGLNTAAYTSDMENGGWHLAAVPGIDVLLLGHSHTEFPGPHYK
DMQEVDAERGFVRGVPAVMGGFFGKDLGVVELALARRDGRWTVDKEHTHSEVRPICTKKD
DCVPADAAIAPLVAKAHEAAVAHVSTPIGETRLRLSSYFSDVGNMTALSVVNAAERAYVQ
AELPKTHPELANVPVVAAAAAFRTGFGGPDDYTDVPAGPLSLRSAADLYFYPNTLAAVKT
DGAGLKAWLEKSAERFRQIDPSTTAEQPLLNDRMPGYNFDQLQGDISYVIDVTKPAGKRI
VDLRWKGRKVDPKQPFVIVTNNYRASGGGNFPGLDGKNIVLAAPDGTREILAKWLERQRT
LSAKDLPKASWRFAPVKTRGPVVFKGAAGKEAEAREAGVKNVRQVKDNGDGTAVYAIDLS
K