Protein Info for ABZR86_RS15315 in Dyella japonica UNC79MFTsu3.2
Annotation: phenylalanine 4-monooxygenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 68% identical to PH4H_RALSO: Phenylalanine-4-hydroxylase (phhA) from Ralstonia solanacearum (strain GMI1000)
KEGG orthology group: K00500, phenylalanine-4-hydroxylase [EC: 1.14.16.1] (inferred from 72% identity to sml:Smlt0077)MetaCyc: 65% identical to phenylalanine hydroxylase (Chromobacterium violaceum)
Phenylalanine 4-monooxygenase. [EC: 1.14.16.1]
Predicted SEED Role
"Phenylalanine-4-hydroxylase (EC 1.14.16.1)" in subsystem Aromatic amino acid degradation or Pterin biosynthesis (EC 1.14.16.1)
MetaCyc Pathways
- L-phenylalanine degradation I (aerobic) (1/1 steps found)
- L-tyrosine biosynthesis IV (1/1 steps found)
- L-phenylalanine degradation V (2/3 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.14.16.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1I2GIF5 at UniProt or InterPro
Protein Sequence (297 amino acids)
>ABZR86_RS15315 phenylalanine 4-monooxygenase (Dyella japonica UNC79MFTsu3.2) MDHSTPRKVEHQQTDRGYVPVYATGVVEQPWADYSQTDHEVWNTLYRRQRELLKGRACQE FLDGIERFGMGENGIPKFADLNKVLGETTGWELVAVEGLLPDEVFFDHLANRRFPVSWWI RRPDQLDYLSEPDLFHDLFGHVPLLLNPVFADYMQAYGRGGMKAFGIGPEALMNLTRLYW YTVEFGLINTSEGMRIYGAGIVSSKGESIYCLDSAAPNRIGFGLERVMNTRYRIDTFQQT YFVIDSFEQLFDATRPDFTPIYADLKTREAHAAADVLDSDRVFTRGTREGFATDADT