Protein Info for ABZR86_RS15115 in Dyella japonica UNC79MFTsu3.2

Annotation: tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 PF10396: TrmE_N" amino acids 7 to 120 (114 residues), 124.5 bits, see alignment E=6.4e-40 TIGR00450: tRNA modification GTPase TrmE" amino acids 12 to 447 (436 residues), 328.7 bits, see alignment E=7.1e-102 PF12631: MnmE_helical" amino acids 123 to 444 (322 residues), 189.2 bits, see alignment E=2.7e-59 TIGR00231: small GTP-binding protein domain" amino acids 217 to 335 (119 residues), 79.2 bits, see alignment E=3e-26 PF02421: FeoB_N" amino acids 218 to 334 (117 residues), 41 bits, see alignment E=3.5e-14 PF01926: MMR_HSR1" amino acids 218 to 330 (113 residues), 89.3 bits, see alignment E=4.8e-29

Best Hits

Predicted SEED Role

"GTPase and tRNA-U34 5-formylation enzyme TrmE" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2GH70 at UniProt or InterPro

Protein Sequence (447 amino acids)

>ABZR86_RS15115 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE (Dyella japonica UNC79MFTsu3.2)
MSDTADTIAAIASAPGAAGVGVLRVSGPAVPAIAQALLGRMPEARHAHFAAFRDAAGELI
DRGLLLYFPAPASYTGEHVLELQGHGNAVLLDALLRRACELGARLARPGEFTERAFLNGK
LDLAQAEAVADLIAAGSQAGARAALRSMEGEFSRRVDELLQALILLRVHIEAAIDFPEEE
IDFLADPAIARQLQALRKQLAELLRETQRGVRLTDGLRVAIIGRPNAGKSSLLNALAGSD
RAIVTDIAGTTRDVLRENLDLDGVALELVDTAGLRDTDDPVEREGVRRARHELTRADVAL
LVTDAAGADEDQQLFADVQADVERIVLVNKIDLDRRPSHSEMREGSWWLWASAKNGDGLD
VLRDHLKRLAGAGSGEGAFSARRRHVLALERVAEHLDRTADVLRDVHAGELAAEELRQAQ
HALGEITGSYSSDDLLGAIFGSFCIGK