Protein Info for ABZR86_RS14690 in Dyella japonica UNC79MFTsu3.2

Annotation: phosphogluconate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01196: phosphogluconate dehydratase
  • amino acids 6 to 605 (600 residues), 983.9 bits, E=1.2e-300
• PF00920: ILVD_EDD
  • amino acids 70 to 603 (534 residues), 524.3 bits, E=1.8e-161

Best Hits

Swiss-Prot: 63% identical to EDD_RHIME: Phosphogluconate dehydratase (edd) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 65% identity to met:M446_3524)

MetaCyc: 60% identical to phosphogluconate dehydratase (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydratase. [EC: 4.2.1.12]

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• Entner-Doudoroff pathway I (9/9 steps found)
• Entner-Doudoroff shunt (2/2 steps found)

KEGG Metabolic Maps

• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

See A0A1I2ITL8 at UniProt or InterPro

Protein Sequence (606 amino acids)

>ABZR86_RS14690 phosphogluconate dehydratase (Dyella japonica UNC79MFTsu3.2)
MSTPLHPVVAEVTARLRERSRDTRAAYLARIAAAGTGGTHRERLSCGNLAHGFAACGPHD
KAALREGHTPNLGIVTSYNDMLSAHQPYERYPELIRRIARESGITAQVAGGVPAMCDGVT
QGREGMELSLFSRDLIAMATAVSLSHDMFDGTLYLGICDKIVPGLLIGALSFGHLPGIFV
PGGPMPSGITNEQKSKVRQAYAEGKANRAELLEAEAAAYHAPGTCTFYGTANSNQMLMEI
MGLHLPGASFVAPDTPLRDALTAEAVHRVAALSAHGDNHLPIGHIVDERAIINGVIGLHA
TGGSTNHLLHLVAMARAAGIQLRWDDFDALSSVVPLLARVYPNGYADVNQFHDAGGMAFL
IDQLLGAGLLHGDVRTVFGTGLDGYAQVPSLDASGALQWTPVAKESGNRGVLRGMAEPFR
ADGGLRMLAGNLGRAVIKVSSVPDDRQVIEAPAVVFHDQDEVRKAFERGELNRDFIAVVR
FQGPRAIGMPELHKLTPTLAVLQDRGYRIALLTDGRMSGASGRVPAAIHVTPEAQAQGAI
ARIRDGDLIRLDATRGTLDVLVDASEFASRAPATADLSSHHSGMGRELFGLFRQAAAEAD
LGAGVL