Protein Info for ABZR86_RS14645 in Dyella japonica UNC79MFTsu3.2

Updated annotation (from data): DNA repair helicase Lhr
Rationale: Specifically important in stress Cisplatin. Similar to the full length of Lhr from Mycobacterium smegmatis, which is a helicase that is suspected to be involved in DNA repair (see PMC3656269) (SEED_correct)
Original annotation: DEAD/DEAH box helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1484 PF00270: DEAD" amino acids 22 to 211 (190 residues), 99.3 bits, see alignment E=4.2e-32 PF04851: ResIII" amino acids 33 to 207 (175 residues), 27.5 bits, see alignment E=5.4e-10 PF00271: Helicase_C" amino acids 316 to 417 (102 residues), 73.1 bits, see alignment 4.5e-24 PF08494: DEAD_assoc" amino acids 679 to 881 (203 residues), 162.3 bits, see alignment E=2.6e-51

Best Hits

Predicted SEED Role

"Lhr-like helicases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2IVX3 at UniProt or InterPro

Protein Sequence (1484 amino acids)

>ABZR86_RS14645 DNA repair helicase Lhr (Dyella japonica UNC79MFTsu3.2)
MSLQAFHPAVRQWFEGTFPAPTAAQLAAWPSIREGRHTLVAAPTGSGKTLTAFLAAIDGL
VREGLAHGGALPDATTVVYVSPLKALSNDIHINLEAPLEGIRAELAALGLPDVAIRTAVR
TGDTPQAERTLMRRQPPHILVTTPESLYILLGSASGREMLGGTRTVIVDEIHAMASTKRG
SHLALSLERLEALCQRPLLRIGLSATQKPIEEVAKFLVGEGNDATLAAAFTPSPQRGEGW
GEGDRRSVEAGTEKRAMLGRSAIASPGPSSAPPAHTCNIVDVGHTRERDLAIEVTPVPLE
AVMSNDAWELVYNRLAELAQAHRTTLVFVNTRRMAERVARHLSERMGKQAVAAHHGSLAR
EQRLDAEQRLKRGELKVLVATASLELGIDIGDVDLVCQLSSPRSIAAFLQRAGRSGHAVS
GTPKARLFPTSRDDLIECAALLDCVRRGELDTLAIPPQPLDVLAQQIVAEVACTEWNEDA
LFALVRRAYPYRELPREQFDAIVRMLADGFTTRRGARAAYVHRDAVHKQLRARRGARLTA
VTSGGAIPDTADYLVVLEPQATVIGSVHEDFAVESLAGDIFQLGNTSYRIIRVERDRLRV
EDAHGVPPSIPFWLGEAPGRSDELSHGVSRLREEISARLDEGGVPEVLSWLRNTLGLSEP
AAQQLADYLARAKAALGVLPTQHTLVFERFFDESGGTQLVIHTPWGSRINRAWGLALRKR
FCRQFNFELQAAATEDAIVLSLSTSHSFPLIEVARYLHSNTAEQVLVQALLDAPLFPVRW
RWNATTSLALPRFQGGRKVAPQIQRMRSEDLLATVFPDQVACLENIAGERQIPDHPLVGQ
TLYDCLREAMDVDGLLHILRGLEGGQITVVARDLTTASPLAAEVLTAAPYAYLDDAPLEE
RRTQAVQTRRWSDGDSAEDLGQLDPDAIEAVRGEAWPQVRGADEMHEALSVLGFVSAEEA
AGDAWDHWLEALAQARRATALSLPGHANWQVWVAAEKLPLWQAIHADAAMQPPIEAPAEF
LAQPWTREDALLEMVRGRLVGLGPVTVATLAASLAVDSGDVELALLRLQSEGYVMQGRFT
PAASETEWCERHLLARIHRYTIGRLRREIEPVSRRDFMRFQFDWQHVAPGARLSGPDALP
AAIAQLEGYEAAAGAWEAELLPARIDDYSITWLDDLCRAGRVGWNRLRGATGGSSPVRAT
PIVLLPRKEMALWSSVAGTGQPQDVLLSSRAQAVADALREHGALFFDELMSVAHLLRTEL
EDALGELVAAGRVTADSFAGLRALLLPAAKRDAQRHRRVRRHMLSGIEDAGRWSLVRAPR
EQDGARAESVEHIARTLLRRYGVVFWKLLEREAAWLPTWRELLRVYHRLEARGEIRGGRF
VEGLVGEQFALPEAIGKLRQVRQQPNEGQHVCLSGCDPLNLVGTVLSGNRLPAVIGTRVL
YEDGVAVAALVANKPQWLVESDTAQQQRWKNALLRRAEHEPVHF