Protein Info for ABZR86_RS13515 in Dyella japonica UNC79MFTsu3.2
Annotation: 2,3-diphosphoglycerate-dependent phosphoglycerate mutase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 73% identical to GPMA_BURL3: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA) from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
KEGG orthology group: K01834, phosphoglycerate mutase [EC: 5.4.2.1] (inferred from 73% identity to rpi:Rpic_0209)MetaCyc: 65% identical to 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (Escherichia coli K-12 substr. MG1655)
RXN-15513 [EC: 5.4.2.11]
Predicted SEED Role
"Phosphoglycerate mutase (EC 5.4.2.1)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.4.2.1)
MetaCyc Pathways
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (23/26 steps found)
- superpathway of glucose and xylose degradation (16/17 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
- superpathway of anaerobic sucrose degradation (17/19 steps found)
- Bifidobacterium shunt (14/15 steps found)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (19/22 steps found)
- glycolysis II (from fructose 6-phosphate) (11/11 steps found)
- glycolysis III (from glucose) (11/11 steps found)
- glycolysis I (from glucose 6-phosphate) (12/13 steps found)
- Entner-Doudoroff pathway I (9/9 steps found)
- homolactic fermentation (11/12 steps found)
- gluconeogenesis I (11/13 steps found)
- gluconeogenesis III (10/12 steps found)
- heterolactic fermentation (14/18 steps found)
- Rubisco shunt (8/10 steps found)
- glycolysis IV (8/10 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
- glycolysis VI (from fructose) (8/11 steps found)
- superpathway of hexitol degradation (bacteria) (13/18 steps found)
- glycolysis V (Pyrococcus) (7/10 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (13/19 steps found)
- superpathway of N-acetylneuraminate degradation (15/22 steps found)
- ethene biosynthesis V (engineered) (17/25 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (17/26 steps found)
- photorespiration II (5/10 steps found)
- formaldehyde assimilation I (serine pathway) (7/13 steps found)
- glycerol degradation to butanol (9/16 steps found)
- gluconeogenesis II (Methanobacterium thermoautotrophicum) (8/18 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (20/56 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Glycolysis / Gluconeogenesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.4.2.1 or 5.4.2.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1I2EM15 at UniProt or InterPro
Protein Sequence (247 amino acids)
>ABZR86_RS13515 2,3-diphosphoglycerate-dependent phosphoglycerate mutase (Dyella japonica UNC79MFTsu3.2) MHKLVLIRHGQSQWNLDNRFSGWADVDLTAQGLEEAKEAGRLLKEAGYSFDVAHTSVLKR AVRTLWGVQDEMGLMWIPVLTDWRLNERHYGALTGLNKAETAAKFGEDQVKVWRRSYDIP PPALERADNESVHDPRYAGLDPALIPDTECLKDTVARVLPYWHEVLAPAIRAGQRVVVAA HGNSLRALVKYLDGISDEDIVELNIPNGVPLVYEFDENLKPLRHYYLGDAEAIAAKMAAV ANQGKAR