Protein Info for ABZR86_RS13345 in Dyella japonica UNC79MFTsu3.2

Annotation: thymidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00265: TK
  • amino acids 2 to 185 (184 residues), 168.3 bits, E=8.1e-54

Best Hits

Swiss-Prot: 76% identical to KITH_XANC8: Thymidine kinase (tdk) from Xanthomonas campestris pv. campestris (strain 8004)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 76% identity to xca:xccb100_4360)

MetaCyc: 61% identical to thymidine/deoxyuridine kinase (Escherichia coli K-12 substr. MG1655)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.21]; 2.7.1.145,2.7.1.21 [EC: 2.7.1.145, 2.7.1.21]

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• pyrimidine deoxyribonucleosides salvage (4/5 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.145 or 2.7.1.21

Sequence Analysis Tools

See A0A1I2EQ45 at UniProt or InterPro

Protein Sequence (209 amino acids)

>ABZR86_RS13345 thymidine kinase (Dyella japonica UNC79MFTsu3.2)
MAKLYFYYSAMNAGKTTTLLQSAYNYHERGMRTVILTPALDNRYGDGVVASRIGLKANGR
RFRTDENLLALVEADIAERGPLHCVFIDEAQFLTKAQVWQASDVVDKLNIPVLAYGLRTD
FRGELFEGSRYLLAWADNLEEIKTICHTGRKATMVVRVDERGRAVTEGPQVEIGGNDRYV
SVSRAEFKKITEGRGRIELQQPVLPLGEH