Protein Info for ABZR86_RS13330 in Dyella japonica UNC79MFTsu3.2
Annotation: NADP-dependent phosphogluconate dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 74% identical to 6PGD_ECOLI: 6-phosphogluconate dehydrogenase, decarboxylating (gnd) from Escherichia coli (strain K12)
KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 81% identity to bug:BC1001_5224)MetaCyc: 74% identical to 6-phosphogluconate dehydrogenase, decarboxylating (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydrogenase (decarboxylating). [EC: 1.1.1.44]
Predicted SEED Role
"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- pentose phosphate pathway (8/8 steps found)
- pentose phosphate pathway (oxidative branch) I (3/3 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Glutathione metabolism
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.44
Use Curated BLAST to search for 1.1.1.44
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1I2EQC8 at UniProt or InterPro
Protein Sequence (473 amino acids)
>ABZR86_RS13330 NADP-dependent phosphogluconate dehydrogenase (Dyella japonica UNC79MFTsu3.2) MNRSVEQPVIGVVGMAVMGRNLALNIESRGHTVAIYNRSREKTDEVVAEHPDKRLAPTYT LQEFVDALQKPRRILLMVKAGEATDATIAELKPLLDQGDVLIDGGNTFFQDTIRRERELN AAGLHFIGTGVSGGEEGALHGPSIMPGGPRDAYDLVAPVLTEIAARAPDGEPCVAYMGPN GAGHYVKMVHNGIEYGDMQLIAESYAVLKQVLGLSNEELGKVYAEWNQGELDSYLIAITA DIFGKQDPDTGKAMVDIILDRAAQKGTGKWTSQSALDLAVPLPLITESVFARLLSALKDE RVAASKVLKGPQAQPFAGDRAAFIESVRRALYLSKIVSYAQGFAQLRAASDEYKWNLPYG TIAKIFRAGCIIRARFLQKITDAYAHDAALANLLLDPYFRDIAAQYQQALRDVVSAAVQA GVAVPGFASAIAYYDSYRAERLPANLVQAQRDYFGAHTFERIDRPGSFHADWT