Protein Info for ABZR86_RS12525 in Dyella japonica UNC79MFTsu3.2

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 50 to 73 (24 residues), see Phobius details amino acids 94 to 113 (20 residues), see Phobius details amino acids 135 to 153 (19 residues), see Phobius details amino acids 165 to 186 (22 residues), see Phobius details amino acids 198 to 219 (22 residues), see Phobius details amino acids 247 to 270 (24 residues), see Phobius details amino acids 282 to 305 (24 residues), see Phobius details amino acids 319 to 342 (24 residues), see Phobius details amino acids 354 to 372 (19 residues), see Phobius details amino acids 393 to 412 (20 residues), see Phobius details amino acids 423 to 443 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 24 to 424 (401 residues), 273.8 bits, see alignment E=1.2e-85 PF01554: MatE" amino acids 24 to 183 (160 residues), 81.8 bits, see alignment E=2.4e-27 amino acids 250 to 411 (162 residues), 107.2 bits, see alignment E=3.7e-35

Best Hits

Swiss-Prot: 49% identical to NORM_XANCP: Probable multidrug resistance protein NorM (norM) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 49% identity to xcc:XCC3762)

MetaCyc: 38% identical to multidrug efflux pump MdtK (Escherichia coli K-12 substr. MG1655)
RXN0-2561; TRANS-RXN-347; TRANS-RXN-348; TRANS-RXN-349

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JIB9 at UniProt or InterPro

Protein Sequence (460 amino acids)

>ABZR86_RS12525 MATE family efflux transporter (Dyella japonica UNC79MFTsu3.2)
MFLSPSDRARVAHEIGATVRLALPLIAAQLAAVGTNVVDAVLAGHYSAHVLGAVAVGASI
WALAIVSGIGMMMAVPPSVSQLDGAGRRAEVGAVFRQALWLAAGMGVLLWFGVRHAGPLI
DLIGVDPGLRRDVDAFLHAISWGAPALTCYFALRGLSEGLSMTLPSMFFALAGLCVLAPL
GYVLMFGKLGLEPQGARGVGMATALVLWLEMLGFALYIARHRNYRGLNLGQRFDLPDPRR
IRELLSIGLPMAITLLAEGGLFVAVALALGTLGETVVASHQVALNIASVFFMIPLGLAMA
ITVRVGNAVGRGDAQGVRYAGFCGIGLALLTQVVSASLMLGLPHLIASLYTRDAAVIALA
TQLIVLAGVFQFSDGIQVASNGALRGLKDTRVPMAMTLFAYWMIGMPFGWWLAFRQGLGA
RGMWMGLVAGLSVAALLLFTRFWRNSATERWRRQTSTSPT