Protein Info for ABZR86_RS10225 in Dyella japonica UNC79MFTsu3.2
Annotation: adenosylmethionine--8-amino-7-oxononanoate transaminase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to BIOA_LYSSH: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Lysinibacillus sphaericus
KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 69% identity to tkm:TK90_1249)MetaCyc: 43% identical to lysine-8-amino-7-oxononanoate aminotransferase (Bacillus subtilis)
RXN-14930 [EC: 2.6.1.105]
Predicted SEED Role
"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)
MetaCyc Pathways
- biotin biosynthesis I (14/15 steps found)
- biotin biosynthesis from 8-amino-7-oxononanoate I (4/4 steps found)
- biotin biosynthesis from 8-amino-7-oxononanoate II (4/4 steps found)
- biotin biosynthesis II (5/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.62
Use Curated BLAST to search for 2.6.1.105 or 2.6.1.62
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1I2IHE0 at UniProt or InterPro
Protein Sequence (455 amino acids)
>ABZR86_RS10225 adenosylmethionine--8-amino-7-oxononanoate transaminase (Dyella japonica UNC79MFTsu3.2) MSPNESRNQALAARDLRHLWHPCTQMHDHAGTVPMLPIVRGEGPWLVDADGRRYLDGISS WWTNLFGHANPRIGAALKQQLDTLEHVIFAGFTHEPAIELAERLAQITPAGLERVFLADN GSAAIEVALKMSFHYWLNQGAGQKTRFIALTGSYHGETLGALSVSDVALYRKTYAPLLLT PVLAPSPDAYEAEPGESAEACAARRLGELRVLLEQHAHETCAVIVEPLVQCAGGMRMYHP SYLTGLRALCDEFGVHFIADEIAVGFGRTGTLFACEQAGVSPDFMCLSKGLTGGFLPLSA VLTTTPVYEAFYAEYNAGKAFLHSHSYTGNPLACRAALATLDIFRDEPVLERNRELAAHL ARRLAPLREHPQVADVRQTGMIAAVELVRDKATRAPYPSEERRGLRVYLHGLEHGALLRP LGNVVYFMPPYVVSTDELDHLVDVAIAGIERAIAD