Protein Info for ABZR86_RS09980 in Dyella japonica UNC79MFTsu3.2

Annotation: NAD-dependent epimerase/dehydratase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03807: F420_oxidored
  • amino acids 5 to 66 (62 residues), 22.5 bits, E=5.9e-08
• PF04321: RmlD_sub_bind
  • amino acids 5 to 169 (165 residues), 36.6 bits, E=1.1e-12
• PF01370: Epimerase
  • amino acids 5 to 231 (227 residues), 160.9 bits, E=1.5e-50
• PF16363: GDP_Man_Dehyd
  • amino acids 6 to 296 (291 residues), 112.7 bits, E=1e-35
• PF01073: 3Beta_HSD
  • amino acids 6 to 212 (207 residues), 42.9 bits, E=1.3e-14
• PF13460: NAD_binding_10
  • amino acids 9 to 165 (157 residues), 48.5 bits, E=4e-16

Best Hits

KEGG orthology group: K01784, UDP-glucose 4-epimerase [EC: 5.1.3.2] (inferred from 34% identity to bph:Bphy_2297)

Predicted SEED Role

"UDP-glucose 4-epimerase (EC 5.1.3.2)" in subsystem Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway or Lactose and Galactose Uptake and Utilization or N-linked Glycosylation in Bacteria or Rhamnose containing glycans or linker unit-arabinogalactan synthesis (EC 5.1.3.2)

MetaCyc Pathways

• UDP-α-D-galactose biosynthesis (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis I (1/1 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-galactofuranose biosynthesis (1/2 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• stachyose degradation (4/7 steps found)
• D-galactose detoxification (1/3 steps found)
• UDP-sugars interconversion (2/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.2

Use Curated BLAST to search for 5.1.3.2

Sequence Analysis Tools

See A0A1I2ILJ9 at UniProt or InterPro

Protein Sequence (305 amino acids)

>ABZR86_RS09980 NAD-dependent epimerase/dehydratase family protein (Dyella japonica UNC79MFTsu3.2)
MRDSILILGAAGFIGRHLTQALLDSGHRVMVATRRPETLAHLSAEALNLVTPDDFRAALA
KAHTVIHTASSSTPGSSSGQPLKELQNLTPTLTLLEALHQQPSIRLIYISSGGTLYTNHD
RTPATEKSRIWPRSYHGAGKIAAESFIEAWCSQQAGSATVIRPSNVYGPGQELRVGFGVI
PNGFAKLKRGEAMEIWGDGSATRDYLYIDDFVELCLRILSEPAKSGFEIFNASSGTGTSL
NQLLQQMELVAGTALKRVYHPPRSLDAEHVVIDAMHAAQRLGWAATTPLQKGLEQTWNWL
KPRLP