Protein Info for ABZR86_RS08500 in Dyella japonica UNC79MFTsu3.2

Annotation: propionate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 TIGR02316: propionate--CoA ligase" amino acids 1 to 625 (625 residues), 1153.8 bits, see alignment E=0 PF16177: ACAS_N" amino acids 3 to 57 (55 residues), 82.7 bits, see alignment 2e-27 PF00501: AMP-binding" amino acids 60 to 443 (384 residues), 254.6 bits, see alignment E=2.2e-79 PF13193: AMP-binding_C" amino acids 510 to 589 (80 residues), 87.6 bits, see alignment E=1.3e-28

Best Hits

Swiss-Prot: 59% identical to PRPE_ECOLI: Propionate--CoA ligase (prpE) from Escherichia coli (strain K12)

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 76% identity to sml:Smlt0947)

MetaCyc: 59% identical to propionyl-CoA synthetase (Escherichia coli K-12 substr. MG1655)
Propionate--CoA ligase. [EC: 6.2.1.17]

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2DNM5 at UniProt or InterPro

Protein Sequence (630 amino acids)

>ABZR86_RS08500 propionate--CoA ligase (Dyella japonica UNC79MFTsu3.2)
MDYETFYRHSIEAPEAFWAEQAQLIDWQTPPRQVLDYSRPPFRRWFVGGTTNLCYNAIDR
HLEARGDQLALVAISTETGLTRELSYRQLHREVNVFAAVLAALDVQRGDRVVIYLPNIAE
AVFAMLACARLGAIHSVVFGGFAAHNLALRIDDAQPKLLIAADAGMRGGKVIPYKPLVDA
ALEQSAAPPPHVLIVDRGLDPQMTRVAGRDLDYAQLRKAHEQAEVPVAWLESNEPSYLLY
TSGTTGKPKGIQRDVGGYAVAMAMSVRYIFDIAPGQVMFSTSDVGWAVGHSYNVYGPLIA
GATSLLYEGLPTRPDPGIWWYLCERYSVRTMFSSPTGIRVLKKQDPAWLRKYDLSSLQWL
FLAGEPLDEPTAHWITDGLGVPVIDNYWQTETGWPAITLMPGLELKRVKFGSPGLPAPGY
RMKVIDEATGEEAAPGHKGVLVFEPPLPPGCLSTVWGDDERYLSSYFGHFKELLYSSLDW
AIRDEHGYTTILGRTDDVINVAGHRLGTREIEESVATHPAVAEAAVIGVRDELKGQVPVV
FATLKQDAGTQAGQVAQAMQQRVVDQLGGIARPSRVYVVNALPKTRSGKLLRRSLQALAE
QRDPGDLSTLDDPGALEEIRRALERGPDQT