Protein Info for ABZR86_RS08350 in Dyella japonica UNC79MFTsu3.2

Annotation: protease modulator HflC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 288 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF01145: Band_7" amino acids 22 to 198 (177 residues), 97 bits, see alignment E=6.8e-32 TIGR01932: HflC protein" amino acids 138 to 281 (144 residues), 167.5 bits, see alignment E=1.7e-53

Best Hits

Swiss-Prot: 44% identical to HFLC_HAEIN: Protein HflC (hflC) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K04087, membrane protease subunit HflC [EC: 3.4.-.-] (inferred from 54% identity to tbd:Tbd_0604)

Predicted SEED Role

"HflC protein" in subsystem Hfl operon

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2DQP7 at UniProt or InterPro

Protein Sequence (288 amino acids)

>ABZR86_RS08350 protease modulator HflC (Dyella japonica UNC79MFTsu3.2)
MKFLAGILVVVAVLLGFNSAYVVHEGQSALVLQFGRIVRTGDTPGLHFKLPLIQQAILFD
NRILTLEAQPERYFTSEKKSVNVDFYVKWRIADNAAYYRATAGAELQAANRLSPIVKDAL
RFEFNGRTLQELIAGGRKDITERVRRQTDATARKSLGIAVVDVRIKRIDLPDEVSESVYK
RMRAERLQLANELRSTGRQAAETIQADADRQGQVIRAEAERDAAKIRGEGDAQAAAIYAQ
AYGQDPEFFAFYRSLGAYRKSFDDGKGVLVLKPDSEFLKYFNDGASKR