Protein Info for ABZR86_RS08305 in Dyella japonica UNC79MFTsu3.2

Annotation: aminomethyl-transferring glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 956 transmembrane" amino acids 333 to 353 (21 residues), see Phobius details amino acids 740 to 761 (22 residues), see Phobius details PF02347: GDC-P" amino acids 20 to 439 (420 residues), 596.3 bits, see alignment E=5.2e-183 amino acids 449 to 732 (284 residues), 46.6 bits, see alignment E=3.6e-16 TIGR00461: glycine dehydrogenase" amino acids 21 to 944 (924 residues), 1475.1 bits, see alignment E=0 PF00266: Aminotran_5" amino acids 590 to 745 (156 residues), 23 bits, see alignment E=5.7e-09 PF21478: GcvP2_C" amino acids 772 to 893 (122 residues), 202.2 bits, see alignment E=2.9e-64

Best Hits

Swiss-Prot: 67% identical to GCSP_BORPD: Glycine dehydrogenase (decarboxylating) (gcvP) from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 64% identity to adk:Alide2_2543)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2DS36 at UniProt or InterPro

Protein Sequence (956 amino acids)

>ABZR86_RS08305 aminomethyl-transferring glycine dehydrogenase (Dyella japonica UNC79MFTsu3.2)
MTQNASPSLRDLEHHEAFIERHIGPNDAEIAHMLSAIGYDSLEAMTDAIVPGQIKSAAPL
ALPPAMTEVEALAKIRAIADKNRVFRSFIGQGYYGTHTPNVILRNILENPAWYTAYTPYQ
AEISQGRMEALINFQTMVADLTGMDISNASLLDEATAAGEAMTLAKRSAKSKSNVFFVAD
DVHPQTLEVLRTRADGVDIALHVGPAADASTVDSFGVLLQYPNTYGTIHDYRAVAEAVHA
RGALVAVATDLLALTLIAAPGSWGADIVIGNSQRFGVPFGFGGPHAAYLACRDAYKRSMP
GRLIGVSVDAEGKPAYRLTLQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPDGLQ
RIARRTHRLAAILAATLRKAGLEVGGEFFDTLRITGVDADAIHAKAAGKGLNLRQIHGQC
VGISLDETTTRADVQALAGLFGAELSDIDEVDAATADALPAALLRQDAFLQHPVFNTHHS
EHELLRYMRSLADKDLAMDRTMIPLGSCTMKLNATAEMIPVTWPEFGNIHPLAPAAQTQG
YKQLIDELEAMLVECTGYDAVSLQPNSGAQGEYAGLLAIRAYHRSRGDEHRDVCLIPESA
HGTNPASAQMCGMTVVVTKCDANGNVDLEDIRAKAEKYSERLAALMITYPSTHGVFEEDV
VAICDIVHKHGGQVYTDGANMNALVGLAKPGKWGSDVSHLNLHKTFCIPHGGGGPGVGPC
AVKSHLAPFLPRTLGGEGSVGMVSAASFGSASILPISWMYITLMGQQGLRKATQVALLNA
NYIARRLASHYETLYTGRNGLVAHECILDLRPLKDATGISAEDVAKRLIDFGFHAPTLSF
PVAGTLMVEPTESESQHELDRFIDAMIQIREEIRAIEDGRLDREDNPLKHAPHTANAVAG
SEWTHAYPRELAVFPLPTLRLQKYWPPVARVDNVYGDKNVMCACIPVDAYKEEAEA