Protein Info for ABZR86_RS07755 in Dyella japonica UNC79MFTsu3.2

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 556 TIGR01228: urocanate hydratase" amino acids 11 to 555 (545 residues), 993.9 bits, see alignment E=9.8e-304 PF17391: Urocanase_N" amino acids 13 to 139 (127 residues), 204.3 bits, see alignment E=7e-65 PF01175: Urocanase" amino acids 142 to 350 (209 residues), 297.8 bits, see alignment E=6.8e-93 PF17392: Urocanase_C" amino acids 353 to 547 (195 residues), 309.9 bits, see alignment E=9.2e-97

Best Hits

Swiss-Prot: 84% identical to HUTU_PSEA8: Urocanate hydratase (hutU) from Pseudomonas aeruginosa (strain LESB58)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 85% identity to psu:Psesu_1929)

MetaCyc: 83% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2E166 at UniProt or InterPro

Protein Sequence (556 amino acids)

>ABZR86_RS07755 urocanate hydratase (Dyella japonica UNC79MFTsu3.2)
MNAPTRIDTTRTIRAPRGGELSCKSWLTEAPFRMLQNNLDPEVAENPAELVVYGGIGRAA
RNWECFDAILRALRELNDDETLLIQSGKPVGVFPTHADAPRVLLANSNLVPAWANWEHFN
ELDKKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYAGSLKGKWILTAGLGGMG
GAQPLAASLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIARYTAAGEAKSIA
LLGNAADVLPELVRRGVKPDAVTDQTSAHDPVNGYLPGGWSVEEWFERRKSDPAGTAKAA
KQSMRTHVEAMLAFQRQGIPTFDYGNNIRQMAKDEGCADAFEFPGFVPAYVRPLFCRGVG
PFRWVALSGDPEDIYKTDAKVKELIPDDPHLHRWLDMARERISFQGLPARICWVGLGLRH
KLGLAFNEMVRKGELKAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNAMLNV
AGGATWVSLHHGGGVGMGYSQHSGVVIVCDGSEAADQRIARVLWNDPGTGVMRHADAGYD
IAVQCAKEQGLKLPMR