Protein Info for ABZR86_RS07570 in Dyella japonica UNC79MFTsu3.2

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1065 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 413 (20 residues), see Phobius details amino acids 434 to 458 (25 residues), see Phobius details amino acids 470 to 495 (26 residues), see Phobius details amino acids 537 to 553 (17 residues), see Phobius details amino acids 881 to 901 (21 residues), see Phobius details amino acids 908 to 928 (21 residues), see Phobius details amino acids 936 to 959 (24 residues), see Phobius details amino acids 980 to 1003 (24 residues), see Phobius details amino acids 1011 to 1037 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1038 (1038 residues), 1140 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1053 (1053 residues), 1370 bits, see alignment E=0 PF03176: MMPL" amino acids 342 to 496 (155 residues), 30.4 bits, see alignment E=2.1e-11 amino acids 829 to 1040 (212 residues), 22.4 bits, see alignment E=5.3e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 68% identity to sml:Smlt3171)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2FV72 at UniProt or InterPro

Protein Sequence (1065 amino acids)

>ABZR86_RS07570 efflux RND transporter permease subunit (Dyella japonica UNC79MFTsu3.2)
MPSFFIDRPIFAWVVAILITMVGTIAMLNMGIESYPNIAPPQVVVSATFPGANADTVEKN
VTQVIEQQLTGIDHLLYFSSSSNANGSASITLTFETGTNPDIAQVQVQNKVSLAQPRLPT
AVTQQGVVVAKNNPDFLMFVSLVSTNPAIDGNRLADIIASQVADQVGRIPGVGSTRVIGA
EYAVRIWLNPDKLQGYGLSASAVRDAVSTQNVQFAAGSLGADPAPADQGFTATVSAEGRF
SSPEEFGNIILRANSDGTVVRLSDVARVSFGPQTYGLVSTWNGQPVGGLGVQLLPGANAL
DVATAVRAKMDELAKDFPQGVTWFAPYDTTPFVKVSINEVVHTLVEAIILVFLVMLIFLQ
NIRATIIPTLVIPVALLGTFIGLIGLGFTINQLTLFGMVLAIGIVVDDAIVVIENVERIM
TEEHLPPKEATRKAMGQITGAVVAITVVLAAVFVPSALQAGASGVIYKQFALTIAVSMGF
SAFLALSFTPALCATMLKPTHDQKKNVVYRGFNKMFDWVTHTYSGHISSAARHAPRWMIL
FALICALAGFLYTKLPTSFVPSEDQGFALAIVNLPPGATIKRTEQVMAEMRERIKQSPLN
DSIVGMYQISGFSFVGQSESAGMAFIKLKDWSERKITADELIMQANGVLHGIRDAQIFVV
NLPTIRGLSQFGGIDMYLQARAGQSHGELMQAMGMVLGKSQGNPALLGTRPNSLPDAPLW
DIKVDRVQAESMGLSVSDVYTAIQLTLAPIYVNDFVYGGRVKRVYLQADQPFRMGPDALS
HVFTPSALAGTGSTTTTRSTTNPYNMIPISSVVHTNWGTGSPALTRYNGYAAVEIVASEG
KGYSTGQAMGALQNIVDTGLPKGFGADWTGQSYQEILAGNSATLLLVLSIVIVFLCLAAL
YESWSIPVAVLLVVPLGLLGTVVFSMLRSLPNDMYFKIGMITVIGLAAKNAILIVEFAVE
QQQQGKSLFDAVVTASRLRLRPILMTSMAFILGVFPLAVSTGAGANSRHAIGTGVIGGML
FATFLGLLLIPVFYVVVRRALGDKLDESSHKIRQAHGGGDAQSGH