Protein Info for ABZR86_RS06080 in Dyella japonica UNC79MFTsu3.2

Annotation: NADH-quinone oxidoreductase subunit NuoH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00146: NADHdh
  • amino acids 15 to 327 (313 residues), 417.7 bits, E=1.4e-129

Best Hits

Swiss-Prot: 67% identical to NUOH_CHRVO: NADH-quinone oxidoreductase subunit H (nuoH) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K00337, NADH dehydrogenase I subunit H [EC: 1.6.5.3] (inferred from 67% identity to psu:Psesu_1838)

MetaCyc: 55% identical to MbhM (Pyrococcus furiosus)
Ferredoxin hydrogenase. [EC: 1.12.7.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain H (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• hydrogen production III (1/1 steps found)
• hydrogen production VIII (1/1 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• hydrogen production VI (1/2 steps found)
• superpathway of hydrogen production (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• superpathway of photosynthetic hydrogen production (3/6 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (5/9 steps found)
• Fe(II) oxidation (2/6 steps found)
• L-glutamate degradation VII (to butanoate) (4/12 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism
• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.12.7.2 or 1.6.5.3

Sequence Analysis Tools

See A0A1I1XYN0 at UniProt or InterPro

Protein Sequence (342 amino acids)

>ABZR86_RS06080 NADH-quinone oxidoreductase subunit NuoH (Dyella japonica UNC79MFTsu3.2)
MGEQILNQLVWPVIYILCIAVPVILAVAMFVYWERKVIGWMHVRMGPNKVGPLGLLQAFA
DVVKLLIKEVILPTSANKFLYYLAPLLALVPAMAAWAVIPFNDKMVLANVNAGVLYLLAM
TSLGVYGIILAGWASNSRYALLGAMRSAAQVISYELAMGLCLVCVLVLAGSLNLTDIVHA
QAGSKGIFEWFMWPLLPVFVIYFISGVAETNRAPFDVAEGESEIVAGFHVEYSGSAFAIF
FLAEYANMILVSFLAAILFMGGWLSPFPASVPFLGQGSFFWLFAKAFAFAFLFLWFRASF
PRYRYDQIMRLGWKVFIPITIVWVLVAGCMKYFGWVSIGTGG