Protein Info for ABZR86_RS04425 in Dyella japonica UNC79MFTsu3.2

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 transmembrane" amino acids 174 to 194 (21 residues), see Phobius details amino acids 206 to 227 (22 residues), see Phobius details amino acids 239 to 261 (23 residues), see Phobius details amino acids 267 to 285 (19 residues), see Phobius details amino acids 420 to 442 (23 residues), see Phobius details amino acids 448 to 471 (24 residues), see Phobius details amino acids 743 to 757 (15 residues), see Phobius details amino acids 763 to 781 (19 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 3 to 67 (65 residues), 56.3 bits, see alignment E=1.1e-18 PF00403: HMA" amino acids 92 to 149 (58 residues), 43.3 bits, see alignment 9.9e-15 TIGR01511: copper-translocating P-type ATPase" amino acids 223 to 782 (560 residues), 432.1 bits, see alignment E=7.6e-133 TIGR01525: heavy metal translocating P-type ATPase" amino acids 241 to 782 (542 residues), 465.7 bits, see alignment E=5.1e-143 TIGR01512: cadmium-translocating P-type ATPase" amino acids 268 to 783 (516 residues), 350.4 bits, see alignment E=3.3e-108 TIGR01494: HAD ATPase, P-type, family IC" amino acids 275 to 760 (486 residues), 216.1 bits, see alignment E=1.4e-67 PF00122: E1-E2_ATPase" amino acids 309 to 481 (173 residues), 146.5 bits, see alignment E=1.6e-46 PF00702: Hydrolase" amino acids 498 to 695 (198 residues), 81.4 bits, see alignment E=2.9e-26 PF08282: Hydrolase_3" amino acids 669 to 714 (46 residues), 26.3 bits, see alignment 1.5e-09

Best Hits

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I1X4V1 at UniProt or InterPro

Protein Sequence (802 amino acids)

>ABZR86_RS04425 heavy metal translocating P-type ATPase (Dyella japonica UNC79MFTsu3.2)
MSACFHCHEPLPHEPVLARIGGEPCAFCCIGCRAAAEWIEQLGLGDYYRLRSAPARKAEQ
STEASATWSCPELDRHVVRPLDGARSEVCLLIEGVRCAACVWLIERSLGTLPGVAQVQVN
AAAARCRVVWDPARTPLPALLDNLARTGYRALPLDARALDDARRRETRDALKRLAVAGFG
SMQAMMYGVALYVGAFQDMDASTRELLRWIGFLLATPVVLYAARPFFAGALRNLRARRLG
MDVPVALAVSLIYAASLAEALRGGAEVYFDSVSMFVFFLLLGRFLEMRARHRSGDLVDAL
ARLTPMFADRCRADGAFERIGAAELRVGDVVHVAEGGGVPADGVLLDRACHVDEALLTGE
AEPVARHPGDSLIAGSVLQDGPVRLRVERVGADTALAGIVALVHRAQAERPRLALAGERA
AARFVARVLALTALTALGWSLLDPSRVLTATLAVLVVSCPCAFALAVPAAMTRALAVLAH
RGVLVAHADAVEKLAEADHVVFDKTGTLTSPHVQQVGGDAAALPLAAALARASSHPLARA
IVDIAAGEDALPAATDVAAHPGMGVEGTVTGRRLRLGRADFALRGTLDAHALADAVVLAD
RHGVLATFHPRERLRDGAAACVHALQAQGLAVEVLSGDAAHRVGAIAQAIGAGQWHARQT
PADKLARLRELRAEGARVIAVGDGINDAPVLAGADIAVAMGNGTPLAQVSSDIVLTGGRL
QALPEARRLAQQTLRILGQNHRWSLCYNLCVVPPAALGLMPPWLAAIGMSASSLLVVLNA
LRIGRAESMPPAEAAALREVHA