Protein Info for ABZR86_RS03225 in Dyella japonica UNC79MFTsu3.2

Annotation: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08267: Meth_synt_1
  • amino acids 5 to 307 (303 residues), 391.5 bits, E=3.7e-121
• TIGR01371: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • amino acids 7 to 757 (751 residues), 1092.1 bits, E=0
• PF01717: Meth_synt_2
  • amino acids 157 to 331 (175 residues), 22.8 bits, E=5.4e-09
  • amino acids 431 to 753 (323 residues), 513.1 bits, E=3.4e-158

Best Hits

Swiss-Prot: 70% identical to METE_XYLFA: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE) from Xylella fastidiosa (strain 9a5c)

KEGG orthology group: K00549, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC: 2.1.1.14] (inferred from 72% identity to xal:XALc_0169)

MetaCyc: 51% identical to cobalamin-independent methionine synthase (Saccharomyces cerevisiae)
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. [EC: 2.1.1.14]

Predicted SEED Role

"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)" in subsystem Methionine Biosynthesis (EC 2.1.1.14)

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• aspartate superpathway (21/25 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• S-adenosyl-L-methionine salvage II (3/3 steps found)
• L-methionine biosynthesis II (5/6 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)
• L-methionine biosynthesis III (3/4 steps found)
• L-methionine biosynthesis I (3/5 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• superpathway of seleno-compound metabolism (6/19 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.14

Sequence Analysis Tools

See A0A1I1ZIH0 at UniProt or InterPro

Protein Sequence (763 amino acids)

>ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (Dyella japonica UNC79MFTsu3.2)
MTTVTNLGFPRMGARRELKQALEAYWRDETQRAPLLDTAGQLRERHWKMQREAGAHVVPC
NDFSLYDHVLDTAWLFDAIPERYRALADADPLAGYFAMARGTQRAGVDLHALEMTKWFDT
NYHYIVPELHAGQAFRLRGDKPVQEFLEARAQGHEARPVLLGPVSFLLLSKTSDGSDRLA
LLDRLLPAYAELLGKLHDAGAEWVQLDEPCLVLDLDHEDAAAYRSAYAALAGTTRPKLLL
ATYFGALGDNLPLAQELPVDGLHIDLVRAPAQLDAVLGSLPADRVLSLGVVDGRNVWRAD
LDRAMAITRVAIERLGRQRVWLAPSCSLLHVPLDASLEKALPADVHAWLAFARQKLEELR
TVADMCKGVVTAYPALEHAREVIAARRASPKVHRLAVAQRLANLDASAAHRRSTYAFRRG
KQQQRFQLPLFPTTTIGSFPQTAEVREARARYKSGQWSAAEYDALIAEQTAACVQFQEAI
GIDVLVHGEFERNDMVEYFGEQLDGFVFTRHGWVQSYGSRCVKPPIIYGDVQRPAPMTVR
WSAYAQALTGRPVKGMLTGPVTVLQWSFVRDDQPRATTCRQLALALRDEVLDLEAAGIRI
IQIDEPALREGLPLRRADWAGYLGWAVESFRLAASGVADDTQIHTHMCYSEFNDIIEAVA
AMDADVISIETSRSRMELLGAFERFRYPNEIGPGVYDIHSPRVPDVAEMVALLEKAGEVL
SPEQLWVNPDCGLKTRGWEETRKALVSLVEAARVMRERMTIAV