Protein Info for ABZR86_RS02155 in Dyella japonica UNC79MFTsu3.2

Annotation: AMP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 31 to 420 (390 residues), 300.5 bits, E=1.6e-93
• PF13193: AMP-binding_C
  • amino acids 471 to 545 (75 residues), 74 bits, E=1.5e-24

Best Hits

Swiss-Prot: 60% identical to LCFA_ECOL6: Long-chain-fatty-acid--CoA ligase (fadD) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K01897, long-chain acyl-CoA synthetase [EC: 6.2.1.3] (inferred from 72% identity to psu:Psesu_1699)

MetaCyc: 60% identical to long-chain-fatty-acid--CoA ligase (Escherichia coli K-12 substr. MG1655)
Long-chain-fatty-acid--CoA ligase. [EC: 6.2.1.3]; 6.2.1.3 [EC: 6.2.1.3]; 6.2.1.3 [EC: 6.2.1.3]; 6.2.1.3 [EC: 6.2.1.3]; 6.2.1.3 [EC: 6.2.1.3]

Predicted SEED Role

"Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)" in subsystem Biotin biosynthesis or n-Phenylalkanoic acid degradation (EC 6.2.1.3)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• palmitate biosynthesis III (28/29 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• oleate β-oxidation (32/35 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• fatty acid salvage (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• long-chain fatty acid activation (1/1 steps found)
• phytol degradation (3/4 steps found)
• stearate biosynthesis IV (4/6 steps found)
• γ-linolenate biosynthesis II (animals) (1/2 steps found)
• linoleate biosynthesis II (animals) (1/2 steps found)
• long chain fatty acid ester synthesis (engineered) (2/4 steps found)
• phosphatidylcholine acyl editing (2/4 steps found)
• alkane biosynthesis II (1/3 steps found)
• oleate biosynthesis I (plants) (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• octane oxidation (2/5 steps found)
• wax esters biosynthesis II (1/4 steps found)
• 6-gingerol analog biosynthesis (engineered) (2/6 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• stearate biosynthesis I (animals) (1/6 steps found)
• 2-deoxy-D-ribose degradation II (2/8 steps found)
• arachidonate biosynthesis III (6-desaturase, mammals) (1/7 steps found)
• capsaicin biosynthesis (1/7 steps found)
• icosapentaenoate biosynthesis II (6-desaturase, mammals) (1/7 steps found)
• icosapentaenoate biosynthesis III (8-desaturase, mammals) (1/7 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• sporopollenin precursors biosynthesis (4/18 steps found)
• cutin biosynthesis (1/16 steps found)
• suberin monomers biosynthesis (2/20 steps found)

KEGG Metabolic Maps

• Fatty acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.3

Sequence Analysis Tools

See A0A1I2A6W5 at UniProt or InterPro

Protein Sequence (562 amino acids)

>ABZR86_RS02155 AMP-binding protein (Dyella japonica UNC79MFTsu3.2)
MSNERPWLAHYPEGVPAQIDLHAYASVAAVLEEAFAKFRDRPAFHSFGKELSYGQIDELS
RQFAGYLTGVLKLGKGDRIAIMMPNVLQYPIALFGALRAGLVVVNTNPMYTARELKHQLE
DAGAKAIVVLDNFAATLQQVVAETEVEHIVTTGIGDLLGLKGTLINFVLKHIKKMVPDYR
LPHAVRFRDALAQGAAHPVPKVDLGHDDLAFLQYTGGTTGVAKGAMLSHGNMVANMLQAG
AWIGTNAKPGEEVIITALPLYHIFSLTANGLVFTRLGGLNWLITNPRDMPGFVKELKKSR
FTALTGVNTLFNGLLNTPGFAEVDFSRLHLSLGGGMAVQRAVAERWKKVTGVTLAEAYGL
TETSPAACINPLDLKDYNSSIGLPIPSTDVAIWSEDSQPLPIGEVGELMVKGPQVMQGYW
KRPDETAKVLGADGWLHTGDIARMDANGYVYIVDRKKDMILVSGFNVYPNEVEDIVMTHP
GVAEVAAVGVPDEHSGEVVKLFVVRKDPNLTVEALKEFCRENLTGYKRPKLIEFRDALPK
SNVGKILRRELRDEKKAASPAA