Protein Info for ABZR86_RS02135 in Dyella japonica UNC79MFTsu3.2

Annotation: pseudouridine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 PF01479: S4" amino acids 25 to 70 (46 residues), 30.8 bits, see alignment 1.9e-11 PF00849: PseudoU_synth_2" amino acids 89 to 219 (131 residues), 79.2 bits, see alignment E=4e-26 TIGR00093: pseudouridine synthase" amino acids 93 to 252 (160 residues), 175.9 bits, see alignment E=2.7e-56

Best Hits

Predicted SEED Role

"Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70)" in subsystem Two cell division clusters relating to chromosome partitioning (EC 4.2.1.70)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.70

Use Curated BLAST to search for 4.2.1.70

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2A7R9 at UniProt or InterPro

Protein Sequence (496 amino acids)

>ABZR86_RS02135 pseudouridine synthase (Dyella japonica UNC79MFTsu3.2)
MNAPQKSLLTLKRDTRTTDAPALEERLHKVLANAGLGSRRMLEQRIQAGEVEVNGSAAGI
GASVHAGDRVVLDGKQFVVATDNRDETEVLVYHKPEGVVTTREDPEGRPTVFEQLPRLKG
ARWVAVGRLDINTTGLLLLTTDGELANALMHPRSALEREYLCRVHGEVPDEIIEKLKSGV
ELEDGPARFDEIGVISRGGSHSWFRVVIREGRNREVRRLWDSQGFLVSRLKRIRYGSVQL
PRALRRGDCETLGEEAVKELRQVSGLGAPQPVLTLSPVLHQRRATRNVTEYRPERGAGGA
WSGAYADEARELRAFDRIREEPARGKQQQRRRPGKEVNGNVARPERGPNANAGRRKGGGK
RGVAPGQELPSVRTWFAGESREGGGGSGGGQGQGYGGGNRRSGSGGGKRGPGGQAQGGGN
PYGGFGGGGGGGNRGYGGGQGAQGNKGGRPQARSGGGNRPGGQGGNRPTQGGGNRHGGGG
ARPHGGGRGGPRGGNR