Protein Info for ABZR86_RS00570 in Dyella japonica UNC79MFTsu3.2

Annotation: acetoacetyl-CoA reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 TIGR01829: acetoacetyl-CoA reductase" amino acids 4 to 244 (241 residues), 374.9 bits, see alignment E=9.4e-117 PF00106: adh_short" amino acids 5 to 196 (192 residues), 202 bits, see alignment E=2.4e-63 PF08659: KR" amino acids 5 to 170 (166 residues), 93.4 bits, see alignment E=6e-30 PF01370: Epimerase" amino acids 6 to 200 (195 residues), 38.5 bits, see alignment E=3.2e-13 PF05368: NmrA" amino acids 7 to 73 (67 residues), 28.2 bits, see alignment E=4.6e-10 PF16363: GDP_Man_Dehyd" amino acids 7 to 75 (69 residues), 28.6 bits, see alignment E=3.6e-10 PF13460: NAD_binding_10" amino acids 10 to 152 (143 residues), 36.5 bits, see alignment E=1.6e-12 PF13561: adh_short_C2" amino acids 13 to 241 (229 residues), 199.4 bits, see alignment E=2.4e-62

Best Hits

Swiss-Prot: 54% identical to PHAB_ALLVD: Acetoacetyl-CoA reductase (phaB) from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D)

KEGG orthology group: K00023, acetoacetyl-CoA reductase [EC: 1.1.1.36] (inferred from 76% identity to sml:Smlt3325)

MetaCyc: 54% identical to hydroxyvaleryl-CoA reductase / acetoacetyl-CoA reductase (Cupriavidus necator)
Acetoacetyl-CoA reductase. [EC: 1.1.1.36]; 1.1.1.36 [EC: 1.1.1.36]

Predicted SEED Role

"Acetoacetyl-CoA reductase (EC 1.1.1.36)" in subsystem Acetyl-CoA fermentation to Butyrate or Polyhydroxybutyrate metabolism or Serine-glyoxylate cycle (EC 1.1.1.36)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.36

Use Curated BLAST to search for 1.1.1.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2CG35 at UniProt or InterPro

Protein Sequence (246 amino acids)

>ABZR86_RS00570 acetoacetyl-CoA reductase (Dyella japonica UNC79MFTsu3.2)
MTQRTALVTGGTGGIGTAIVRYLARQGHRVATNYRDPARADAWRAAIAQEGIEVAMVQGD
VSDPASCEAMVRELESKLGAVEILVNNAGITRDTTFHKMSYQQWTDVVNTNLNACFNVTR
PVIDGMRGRKWGRIVQISSINGQKGQYGQANYAAAKAGMHGFTISLAQENAKFGITVNTV
SPGYVATDMVMAVPEEVREKIVAQIPVGRLGKPEEIAHAVAFLTGEEAAWITGTNLAING
GHYMGW