Protein Info for ABIE53_006148 in Paraburkholderia graminis OAS925

Annotation: betaine-aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01804: betaine-aldehyde dehydrogenase
  • amino acids 10 to 476 (467 residues), 728.9 bits, E=1e-223
• PF00171: Aldedh
  • amino acids 15 to 478 (464 residues), 601.4 bits, E=5.1e-185

Best Hits

Swiss-Prot: 93% identical to BETB_PARXL: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 94% identity to bug:BC1001_5833)

MetaCyc: 70% identical to betaine aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]

Predicted SEED Role

"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)

MetaCyc Pathways

• choline-O-sulfate degradation (3/3 steps found)
• glycine betaine biosynthesis III (plants) (3/3 steps found)
• choline degradation I (2/2 steps found)
• glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
• glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
• β-alanine biosynthesis I (1/2 steps found)
• β-alanine biosynthesis IV (1/2 steps found)
• choline degradation IV (2/4 steps found)
• dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
• dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.8

Protein Sequence (489 amino acids)

>ABIE53_006148 betaine-aldehyde dehydrogenase (Paraburkholderia graminis OAS925)
MAVFAMQRLYIGGAYVDATSGETFDTVDPATGETLATVQQASAADVDRAVQSARDGQREW
AALTAMQRSRILRRAVEILRERNDELALLETRDTGKPIAETQAVDIVTGADVIEYYAGLA
TAIEGQQIPLRPSSFVYTRREPLGVCAGIGAWNYPIQIACWKSAPALAAGNAMIFKPSEV
TPLTALKLAEIYTEAGVPPGVFNVVQGDGRVGAMLAAHPDIEKISFTGGVETGKKVMSMA
GASSLKEVTMELGGKSPLLVFDDANLERAADIAMSANFFSSGQVCTNGTRVFVQRNVIER
FEALLLERVKRIRVGAPTGASTNFGPLVSAAQLQKVLGYIESGVKEGARLIAGGKRLTEN
HYAQGQYVEPTIFTGCHDDMRIVREEIFGPVMSILVFDEEDEAIERANRTAYGLAAGVVT
ENLARAHRVIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQV
ELGPYQPVF