Protein Info for ABIE53_005773 in Paraburkholderia graminis OAS925

Annotation: glutamate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01788: glutamate decarboxylase
  • amino acids 10 to 427 (418 residues), 527 bits, E=1.6e-162
• PF00282: Pyridoxal_deC
  • amino acids 38 to 359 (322 residues), 205.2 bits, E=6.6e-65

Best Hits

Swiss-Prot: 46% identical to DCE_SOLLC: Glutamate decarboxylase from Solanum lycopersicum

KEGG orthology group: K01580, glutamate decarboxylase [EC: 4.1.1.15] (inferred from 82% identity to bbr:BB2658)

MetaCyc: 46% identical to glutamate decarboxylase (Solanum lycopersicum)
Glutamate decarboxylase. [EC: 4.1.1.15]

Predicted SEED Role

"Glutamate decarboxylase (EC 4.1.1.15)" in subsystem Acid resistance mechanisms (EC 4.1.1.15)

MetaCyc Pathways

• GABA shunt I (4/4 steps found)
• GABA shunt II (4/4 steps found)
• L-glutamate degradation IX (via 4-aminobutanoate) (1/1 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Taurine and hypotaurine metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.15

Protein Sequence (452 amino acids)

>ABIE53_005773 glutamate decarboxylase (Paraburkholderia graminis OAS925)
MTPYDEFNLEVPENAFPQQGMSAKAAAALVISDEWTDANPMLNMSSFVTTWAEPEAAEVA
KRNIFKNYIDHDMYPQVFATETRMVKWLHQLWNGPAGVEPYGTATIGSSEACMLAGLAHK
WNWRQKREREGKDATRPNMVTGGNVQIVWKKFLRYFDVEPRIVPLRPGNYRLTAEQLDKY
VDENTIAVVAIAGQTFTGEDDDIKGIHDWLDAYEQKTGISVPMHIDGASGGFVNPFLYPD
YEWDFRLPRVQSINASGHKYGLAPPGLGWVVFRERKIFNEDLVFYVNYLGGEMPTATLNF
SRNAFQVAVQYYMFLRLGFDGYRRIMKHTLNNAIALREMIVKSGYFTIMNETQRIPVVAV
TLDKRITNFNEFDVSNKVREKGWVLSAYSMPPDAEEVKSLRIVVRPHINRNSALLLGGDI
IRACRFLAEHGGNATPPRLHTHSVETSSTVKC