Protein Info for ABIE53_005702 in Paraburkholderia graminis OAS925

Annotation: two-component system heavy metal sensor histidine kinase CusS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 14 to 34 (21 residues), see Phobius details amino acids 168 to 188 (21 residues), see Phobius details PF21085: CusS" amino acids 7 to 111 (105 residues), 26.8 bits, see alignment E=1e-09 TIGR01386: heavy metal sensor kinase" amino acids 7 to 461 (455 residues), 445.2 bits, see alignment E=1.5e-137 PF00672: HAMP" amino acids 188 to 239 (52 residues), 39 bits, see alignment 1.6e-13 PF00512: HisKA" amino acids 245 to 309 (65 residues), 51.1 bits, see alignment E=2.3e-17 PF02518: HATPase_c" amino acids 354 to 462 (109 residues), 80.1 bits, see alignment E=3.5e-26

Best Hits

KEGG orthology group: K07644, two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC: 2.7.13.3] (inferred from 70% identity to bch:Bcen2424_3409)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>ABIE53_005702 two-component system heavy metal sensor histidine kinase CusS (Paraburkholderia graminis OAS925)
MTARKAPYSLLKRLTAAFAVAALIVFALMGAFLYRSLSQELQRRDDIEIIGKLAQFQQFV
RDAGSIHAVKAAPAIFHEVLLSHPGVYLGIFDAQNRVLVEHVGQEHLDLAAAFSGKHAGG
SPFTCEIASIGSSRCIFSGATLPSHETVRVVLVRAASDRQSLLNSYRVDVLIAVALGAAL
VSTVGYAVTRRGLSPVKSIGRQTSRIEAHNLSERLDIHGGPVELQAIALSVNRMLDRLER
AFVRLSQFSSDLAHDMRTPLANVISSSQVTLSRTRTIDEYEALIDSNIEECERLQRMIEN
MLFLARNENAQQLIHVVKLDATSELSRLASYFQGLAEEAGVNLAVDGNAQLSADATLFRR
AVSNLMSNALDHAFAGSCVELRSFESPKYSVVEVTNRGHAIAPEHVERIFERFYRVDASR
HRSARNAGLGLAIVKSIMELHRGKVEVASNDERTTFTLYFPRPVDV