Protein Info for ABIE53_005649 in Paraburkholderia graminis OAS925

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 530 PF00732: GMC_oxred_N" amino acids 4 to 294 (291 residues), 170.5 bits, see alignment E=1.5e-53 PF00890: FAD_binding_2" amino acids 197 to 303 (107 residues), 24.3 bits, see alignment E=5.4e-09 PF05199: GMC_oxred_C" amino acids 386 to 522 (137 residues), 142.9 bits, see alignment E=3.2e-45

Best Hits

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 52% identity to dsh:Dshi_0804)

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (530 amino acids)

>ABIE53_005649 choline dehydrogenase (Paraburkholderia graminis OAS925)
MESFDYIIVGAGSAGCAVAARLSESGRDTILVLEAGPRDSYPWIHIPLGFGKTFFNTKVN
WCFSTQPSSELNSRALFAPCGKVLGGSSSINGLVYSRGQAQDFDSWRDEGNVGWGYDDVL
PFFRKSENHEHGANAFHGANGPLSVYDVMECHPLSTAFVDSAAAVGFVRNPDFNGASQEG
VGSFQVTARNGRRVSSAVAFLRQAERRPNVHVRTNAEVERLTIESGRVTGLTYSSHGKSI
SVQARRAVVLSAGALNSPAILQRSGIGRAEWLHDAGIKLKHELTGVGANLQDHLQARLVI
RSRRLPTLNTQMRSPVGVVKMGVKYALLRRGPLASAGGQTGGFIRTRAELDRPDIMYFVM
PFTSADLRNGLDRFPGFTIASCLLRPDSRGTVRPQSPNPKDAPLIEPNYLEAESDRTTML
AGLRAARRIAAAEPLRGEIECEERPGPNVESDEELLGYIRATASSVYHPVGTCKMGSGED
AVVDAKLRLHGLDGLRIADASIMPSIVSSPTNATAIMIGERAAAFLLEDM