Protein Info for ABIE53_005280 in Paraburkholderia graminis OAS925

Annotation: cytochrome c oxidase subunit I+III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 649 transmembrane" amino acids 55 to 75 (21 residues), see Phobius details amino acids 97 to 122 (26 residues), see Phobius details amino acids 134 to 155 (22 residues), see Phobius details amino acids 180 to 204 (25 residues), see Phobius details amino acids 218 to 241 (24 residues), see Phobius details amino acids 271 to 294 (24 residues), see Phobius details amino acids 302 to 324 (23 residues), see Phobius details amino acids 338 to 361 (24 residues), see Phobius details amino acids 372 to 393 (22 residues), see Phobius details amino acids 409 to 431 (23 residues), see Phobius details amino acids 446 to 466 (21 residues), see Phobius details amino acids 487 to 509 (23 residues), see Phobius details amino acids 593 to 611 (19 residues), see Phobius details amino acids 617 to 634 (18 residues), see Phobius details TIGR02891: cytochrome c oxidase, subunit I" amino acids 43 to 547 (505 residues), 698.6 bits, see alignment E=2.3e-214 PF00115: COX1" amino acids 51 to 495 (445 residues), 500 bits, see alignment E=3.1e-154

Best Hits

Swiss-Prot: 42% identical to COX1_COREF: Cytochrome c oxidase subunit 1 (ctaD) from Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 96% identity to bug:BC1001_5387)

Predicted SEED Role

"Cytochrome c oxidase polypeptide I (EC 1.9.3.1) / Cytochrome c oxidase polypeptide III (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (649 amino acids)

>ABIE53_005280 cytochrome c oxidase subunit I+III (Paraburkholderia graminis OAS925)
MSERHSTSARPIEHLVDGPAAGPQITEALARTWSDPPGWLGRLSAINHKTVARRFVITTF
VFFLLAGLLALAMRLQLARPGNRLVGPELYNQLFTIHGTTMMFLFAVPVMQAVAGWLVPL
MIGARSVAFPRMNAYAYWVFLFGGATLYVAFLLGAGPDAGWFSYVPLAGPDYSTGKGVDI
WAQMITFTELSGLLEAVVLITTIFKMRAPGMSLNRMPLFVWATLITQFMVLFAMPAVMLS
STALILDRLVGTHFYNAARGGDVLLWQHLFWFFGHPEVYLIFIPPLGFLSSIIPTFARRP
IFGYPAMVLALITTAFLAFGLWVHHMFATSIPALGKSFFTAASLMIAIPSGVQIFCWIAT
LWTGRVNLKTPLWFALGFFFILVLGGMTGVMLGSVSLDLQVHDTYFVVAHLHYVLLGGAV
FPLFGAFYYWFPKATGRMLNETLGRLQFWLFFIGFNVTFFPMHILGLHGMPRRVWTYPHA
MGWDGLNMTATIGAITIAVSVLIFIVNVLRSYRHGAIAGADPWGAGTLEWSTASPPPPHN
FDALPVVHGRDPLWEPGAQPTHVSGLAAESREVLSTTALDALPDLRLLFPSPSIWPFISA
VATTVLFIGSIFSPWAVVWGSVPVIVAMIGWFWPNRGQNRRALQLEQRP