Protein Info for ABIE53_005190 in Paraburkholderia graminis OAS925

Annotation: 4-hydroxy-tetrahydrodipicolinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 4 to 274 (271 residues), 205.3 bits, E=4.3e-65
• TIGR00674: 4-hydroxy-tetrahydrodipicolinate synthase
  • amino acids 11 to 280 (270 residues), 240.2 bits, E=1e-75

Best Hits

Swiss-Prot: 38% identical to DAPA_PELPD: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 87% identity to bug:BC1001_5287)

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (15/18 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• dipicolinate biosynthesis (3/4 steps found)
• L-lysine biosynthesis II (6/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7

Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7

Protein Sequence (287 amino acids)

>ABIE53_005190 4-hydroxy-tetrahydrodipicolinate synthase (Paraburkholderia graminis OAS925)
MSIFSGIWIPLITPFADGAVDHAALRALVRRYADADVAGIVALGTTGEPAALDAAEQDAV
LATILEAAHDAPLPVVVGVSGNNTASMRERIQELNSLPIAGVLMAAPYYVRPSQAGIVSH
FIALADASDKPVVLYDIPQRTGVRLELDTLLALAGHPRIQAVKDCAGSLDTTLALIRDGR
LQVLAGEDLQMFNTLCMGGSGAIAASAHVRTERFVALYRALAAGALDEARRIFHTLVPLI
HALFAEPNPAPVKASLALQGLIRDELRLPMTRASGILAQRLAALERA