Protein Info for ABIE53_004881 in Paraburkholderia graminis OAS925

Annotation: succinate dehydrogenase / fumarate reductase membrane anchor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 122 transmembrane" amino acids 25 to 46 (22 residues), see Phobius details amino acids 59 to 83 (25 residues), see Phobius details amino acids 98 to 120 (23 residues), see Phobius details PF01127: Sdh_cyt" amino acids 2 to 108 (107 residues), 57.6 bits, see alignment E=7.2e-20 TIGR02968: succinate dehydrogenase, hydrophobic membrane anchor protein" amino acids 16 to 120 (105 residues), 125 bits, see alignment E=6.6e-41

Best Hits

Swiss-Prot: 35% identical to DHSD_SHIFL: Succinate dehydrogenase hydrophobic membrane anchor subunit (sdhD) from Shigella flexneri

KEGG orthology group: K00242, succinate dehydrogenase hydrophobic membrane anchor protein (inferred from 100% identity to bug:BC1001_4888)

MetaCyc: 35% identical to succinate:quinone oxidoreductase, membrane protein SdhD (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Succinate dehydrogenase hydrophobic membrane anchor protein" in subsystem Succinate dehydrogenase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (122 amino acids)

>ABIE53_004881 succinate dehydrogenase / fumarate reductase membrane anchor subunit (Paraburkholderia graminis OAS925)
MAANNRIGSKRLVVGAHYGLRDWLAQRITACVMALYTVILLAWFFGARDFSYEGWASIFA
TQWMKLATFVTLLSLFYHAWVGIRDIWMDYVKPVGVRLLLQALTIVWLLACAGYAAQILW
RV