Protein Info for ABIE53_004295 in Paraburkholderia graminis OAS925

Annotation: ornithine cyclodeaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02992: ectoine utilization protein EutC
  • amino acids 4 to 327 (324 residues), 497.6 bits, E=7.2e-154
• PF02423: OCD_Mu_crystall
  • amino acids 14 to 319 (306 residues), 198.3 bits, E=1.6e-62
• PF01488: Shikimate_DH
  • amino acids 123 to 221 (99 residues), 43.5 bits, E=3.5e-15

Best Hits

Swiss-Prot: 59% identical to Y0419_RHIME: Putative dehydrogenase RB0419 (eutC) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01750, ornithine cyclodeaminase [EC: 4.3.1.12] (inferred from 95% identity to bgf:BC1003_5084)

Predicted SEED Role

"Ornithine cyclodeaminase (EC 4.3.1.12)" in subsystem Arginine and Ornithine Degradation (EC 4.3.1.12)

MetaCyc Pathways

• L-ornithine degradation I (L-proline biosynthesis) (1/1 steps found)
• L-arginine degradation VII (arginase 3 pathway) (1/2 steps found)
• L-proline biosynthesis II (from arginine) (1/2 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.12

Use Curated BLAST to search for 4.3.1.12

Protein Sequence (333 amino acids)

>ABIE53_004295 ornithine cyclodeaminase (Paraburkholderia graminis OAS925)
MTSITLLGEAQLRELVPLDLAAIDQVEAAFLALATEDVAMPPILRLDLPAQNGEVDVKTA
YLPRFDSFAIKVSPGFFNNPALGLPSLNGLMLVLSAKTGLTEAVLLDNGYLTAVRTAAAG
AVAARWLAKQHTPQVAVLGAGEQARLQLQALMLVRRVEHVRVWARNRSNAERFAEEMTAT
LGVRCEAARDVAHALAEADVAITTTPSRTPLIEAAHLHAGLHITAMGSDAEHKNEIAPAA
LAAARYICDRVQQTRVLGELHHALNARAIKADASIAELGEVIAGKAVGRTSDTDVTICDL
TGTGAQDTAIAALALQRARAANAGTVFRNDVER