Protein Info for ABIE53_004258 in Paraburkholderia graminis OAS925

Annotation: beta-alanine--pyruvate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 25 to 436 (412 residues), 294.2 bits, E=1.4e-91
• PF00155: Aminotran_1_2
  • amino acids 203 to 349 (147 residues), 24.5 bits, E=1.5e-09

Best Hits

Swiss-Prot: 52% identical to BAUA_PSEAE: Beta-alanine--pyruvate aminotransferase (bauA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00822, beta-alanine--pyruvate transaminase [EC: 2.6.1.18] (inferred from 97% identity to bgf:BC1003_5131)

Predicted SEED Role

"Omega-amino acid--pyruvate aminotransferase (EC 2.6.1.18)" in subsystem Pyruvate Alanine Serine Interconversions (EC 2.6.1.18)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
• β-alanine biosynthesis II (5/6 steps found)
• β-alanine degradation II (2/2 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.18

Use Curated BLAST to search for 2.6.1.18

Protein Sequence (442 amino acids)

>ABIE53_004258 beta-alanine--pyruvate transaminase (Paraburkholderia graminis OAS925)
MTSRPVIDDLSSFWMPFTANRQFKAAPRLLESAKGMYYRSTDGREVLDGCAGLWCVNAGH
SRDEIVAAITKQLSTLDFAPTFQMGHPLAFEAATRVAELMPEGLDRIFFTNSGSESVDTA
LKIALAYHRSRGEAQRTRLIGRERGYHGVGFGGISVGGIAPNRKTFSGALLPAVDHLPHT
HNLEQNAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSTGVLIPPQGYLQKL
RDICTKHGILLIFDEVITGFGRVGKATASEYFGVTPDLITMAKAINNASIPMGAVAASRT
VHDTIVNGGAQGAIELFHGYTYSAHPAAVAAAIATLDLYRSEGLFERAASLAPTFEAAVH
SLRGAKHVKDIRNLGMIAGIELESRDGAPGARAYEAFVKCFEAGVLVRFTGDILAFSPPL
IINEEQIAHLFKTVGDVLATVQ