Protein Info for ABIE53_004062 in Paraburkholderia graminis OAS925

Annotation: beta-galactosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02449: Glyco_hydro_42
  • amino acids 6 to 388 (383 residues), 491.9 bits, E=1.6e-151
• PF08532: Glyco_hydro_42M
  • amino acids 405 to 605 (201 residues), 121.3 bits, E=4e-39

Best Hits

KEGG orthology group: K12308, beta-galactosidase [EC: 3.2.1.23] (inferred from 93% identity to bug:BC1001_4096)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

• lactose degradation III (1/1 steps found)
• xyloglucan degradation II (exoglucanase) (3/8 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Glycosaminoglycan degradation
• Glycosphingolipid biosynthesis - ganglio series
• Other glycan degradation
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Protein Sequence (661 amino acids)

>ABIE53_004062 beta-galactosidase (Paraburkholderia graminis OAS925)
MRLGVCYYPEHWPESMWEDDARRMKALGIEQVRIAEFAWSRIEPTPGEYDWAWLDRAIEV
LGAAGLQVVMCTPTATPPKWLIDRHPDILPIGADGRPRAFGSRRHYDFSSPSYFAASQKI
CTAIAERYGKHPAVRYWQTDNEFGCHHTVVSYSPAAVERFREWLKARYQTVDALNRAWGT
VFWSMEYRSFDEIDAPVATVTEAHPSHRLDYRRFASDEVARYNRMQVEIIRAHSPGRPIA
HNFMQLFTEFDHYNVAADLDVAAWDSYPLGALEEQWFAPDVKARWLRSGHPDFASFNHDV
YRGMSKLPFWVMEQQPGPVNWAMWNPAPLPGMVRLWSWEAFAHGAGCVSYFRWRQAPFAQ
EQMHAGLNTPDNRLDVGGSEAARVAEEIGTVLAANADADAAIRSKVALVYDYEAKWLFEI
HPQGADFHYPRFAFEYYSALRALGLDVDVVPVDASLDGYSLIVVPPLPVVSADLAARLAK
SGAQVVLGPRTGSKTQDLQIPANLPPGPLADVLPLRVWRVESMRPNVTEPVLLDGTQAAN
AGEGVARHWRDFIESNGTNSFDVLARFADGHPAYVRSGAFHYFASLFDDALTVRLFAQIA
QQAGIQTMPLGESVRISRRGALTYVFNYGDCAHTIADVADDAFIIGSRAVEPQGVAAYRS
K