Annotation: tetratricopeptide (TPR) repeat protein
These analyses and tools can help you predict a protein's function, but be skeptical.
For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect.
For other types of proteins, the error rates may be much higher.
MetaCyc and Swiss-Prot have low error rates,
but the best hits in these databases are often quite distant,
so this protein's function may not be the same.
TIGRFam has low error rates.
Finally, many experimentally-characterized proteins are not in any of these databases.
To find relevant papers, use PaperBLAST.
Protein Families and Features
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732
transmembrane "
amino acids 599 to 614 (16 residues), see Phobius details
PF13432: TPR_16 "
amino acids 114 to 171 (58 residues), 29.8 bits, see alignment
5e-10
amino acids 176 to 240 (65 residues), 38.5 bits, see alignment
E=9.2e-13
amino acids 213 to 273 (61 residues), 28.9 bits, see alignment
9.4e-10
amino acids 284 to 340 (57 residues), 27.3 bits, see alignment
2.9e-09
amino acids 354 to 406 (53 residues), 28.9 bits, see alignment
9.5e-10
PF14559: TPR_19 "
amino acids 116 to 175 (60 residues), 29.7 bits, see alignment
4.8e-10
PF13431: TPR_17 "
amino acids 127 to 158 (32 residues), 22.2 bits, see alignment (E = 8.9e-08)
PF00515: TPR_1 "
amino acids 138 to 171 (34 residues), 31.8 bits, see alignment (E = 6.5e-11)
amino acids 206 to 239 (34 residues), 29 bits, see alignment (E = 5.2e-10)
amino acids 310 to 340 (31 residues), 30.5 bits, see alignment (E = 1.7e-10)
PF07719: TPR_2 "
amino acids 138 to 171 (34 residues), 27.3 bits, see alignment (E = 1.9e-09)
amino acids 206 to 238 (33 residues), 28.1 bits, see alignment (E = 1.1e-09)
amino acids 308 to 340 (33 residues), 27.9 bits, see alignment (E = 1.2e-09)
amino acids 342 to 374 (33 residues), 24.2 bits, see alignment (E = 1.9e-08)
PF13181: TPR_8 "
amino acids 138 to 171 (34 residues), 22.5 bits, see alignment (E = 6.5e-08)
amino acids 172 to 197 (26 residues), 11.8 bits, see alignment (E = 0.00018)
amino acids 206 to 238 (33 residues), 26.4 bits, see alignment (E = 3.8e-09)
amino acids 274 to 306 (33 residues), 12.8 bits, see alignment (E = 8.7e-05)
amino acids 309 to 340 (32 residues), 24.8 bits, see alignment (E = 1.3e-08)
amino acids 342 to 374 (33 residues), 15.9 bits, see alignment (E = 8.9e-06)
amino acids 376 to 408 (33 residues), 16.3 bits, see alignment (E = 6.6e-06)
PF13424: TPR_12 "
amino acids 138 to 202 (65 residues), 30.2 bits, see alignment
E=3.1e-10
amino acids 273 to 339 (67 residues), 30.1 bits, see alignment
E=3.3e-10
amino acids 308 to 370 (63 residues), 35.7 bits, see alignment
E=6.1e-12
PF13374: TPR_10 "
amino acids 142 to 168 (27 residues), 16.3 bits, see alignment (E = 6.1e-06)
amino acids 210 to 235 (26 residues), 19.4 bits, see alignment (E = 6.2e-07)
amino acids 279 to 305 (27 residues), 15.1 bits, see alignment (E = 1.5e-05)
amino acids 346 to 370 (25 residues), 15.3 bits, see alignment (E = 1.3e-05)
PF13414: TPR_11 "
amino acids 148 to 183 (36 residues), 30.7 bits, see alignment (E = 1.5e-10)
amino acids 213 to 250 (38 residues), 27.7 bits, see alignment
1.3e-09
amino acids 289 to 321 (33 residues), 27.9 bits, see alignment (E = 1.1e-09)
amino acids 352 to 389 (38 residues), 33.8 bits, see alignment
1.6e-11
PF01075: Glyco_transf_9 "
amino acids 642 to 674 (33 residues), 23.6 bits, see alignment (E = 2.3e-08)
Best Hits
KEGG orthology group: None (inferred from 87% identity to
bug:BC1001_4073 )
Predicted SEED Role "FOG: TPR repeat"
Sequence Analysis Tools PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (732 amino acids) >ABIE53_004037 tetratricopeptide (TPR) repeat protein (Paraburkholderia graminis OAS925)
MGDPARGRRTRNVTGLMTFTQTLASSIAQLNQQAIALYSADEFAAALSTVMPAIEHDEST
LDDAAIHAMADALNIAGASSCRLGHADDAERHWRRCLRIAPGYVEVYESFGALLKARGRL
SAAKAIYRQLIAMRPEHADAHNQLGAVLHAQGHHEEAEVSYRRALSLRPDHAEAHYNHGV
VLQTLRRLHEAEAAYRETLRRLPAHAQAHNNLGNVLMDLGRVDEADAAYRDALSIQPHYP
EALNNLAGALKAAQRLTEAELACRLALTMRPDYAEAHVNLGAALTDLARLPEAESAYRKA
IALCADYAGAHYNLGITLFKLERMEEAAAAYREAVRLRPDIAPAHNNLGCVLRLLDRLPE
AVDAFEQALSTDPDLAEAHYNLGAALAQLTRLPEAESAYRRALSLRADYGDARFGLATLL
LSMGRFEEGWPLYECRYQQTDFVHRQTAQRLSCPQWQGDALSGRSLLVWQEDGLGDMLQF
SRYFALLKAQGAAHIAFACAPALHRLMTRIDGVDSVLDHHTAAARASDYDCWTSLLSAPL
HLRTTIDTIPRPVRLAAEESLVEKWRPVLDALPPGRKIGLVWKGNAKHHNDANRSIPSLV
TLAPLWSVAGLSFVSLQKGQGEDEARNPPSDQPLLHVGSMVTDLADSAAIVAQLDLVICV
DTSIAHLAASLGKPCWVMLPEKDVDWRWMYERSDSPWYPHTLRLFRRERGEEWTSTVERV
RQACVARFGVRE