Protein Info for ABIE53_003081 in Paraburkholderia graminis OAS925

Annotation: MATE family multidrug resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 transmembrane" amino acids 27 to 42 (16 residues), see Phobius details amino acids 61 to 84 (24 residues), see Phobius details amino acids 99 to 126 (28 residues), see Phobius details amino acids 141 to 162 (22 residues), see Phobius details amino acids 172 to 192 (21 residues), see Phobius details amino acids 202 to 226 (25 residues), see Phobius details amino acids 247 to 273 (27 residues), see Phobius details amino acids 282 to 304 (23 residues), see Phobius details amino acids 325 to 349 (25 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 402 to 424 (23 residues), see Phobius details amino acids 430 to 449 (20 residues), see Phobius details PF01554: MatE" amino acids 29 to 188 (160 residues), 78.8 bits, see alignment E=1.9e-26 amino acids 253 to 419 (167 residues), 103.2 bits, see alignment E=6.2e-34 TIGR00797: MATE efflux family protein" amino acids 29 to 432 (404 residues), 244.3 bits, see alignment E=1.1e-76

Best Hits

Swiss-Prot: 84% identical to NORM_BURMA: Probable multidrug resistance protein NorM (norM) from Burkholderia mallei (strain ATCC 23344)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 97% identity to bug:BC1001_2580)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (469 amino acids)

>ABIE53_003081 MATE family multidrug resistance protein (Paraburkholderia graminis OAS925)
MTQSGFTRSAAPPPTFSRHAADTARLAAPLAIAQLSQMAMAVTDTILLGSLGPDALAAGG
LGANLFFVVVTLLQGVLTSVSVSVSHARGAQDESRVPHIYWTGFVLSVLLSVPAFALLSF
ATPILLAFGEPALLAHNVGEYAAVLRWGALGSLIGVGLMRSFLPAIGAARRLLWVSLVSV
GVNGVLNYGLIHGAYGLPRLGFLGSAAATSITVWLTALVLMALLHLRPRYRHFVVATRPN
VPLMGELFGIGWPVAITYGVESTLFLATGLMVGLLGESQLAAHQIALNVASVAFMVPLAI
GQAANVRVGFWSGAGQPLAARHAGFVALALGVGFMTLSGIVLIAAPHWIVGLYLHLDDPA
NAATVALASSLLGVAAIFQIVDGMQTVGSGCLRGLKDTRIPMIAAAFGYWVIGFPTGYTL
AFHFGLGARGLWWGLAAGLASVALLMTLRFHKLSLRRVPAKDAPPAASV