Protein Info for ABIE53_002938 in Paraburkholderia graminis OAS925

Annotation: propionyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02316: propionate--CoA ligase
  • amino acids 3 to 628 (626 residues), 1094.9 bits, E=0
• PF16177: ACAS_N
  • amino acids 4 to 58 (55 residues), 87 bits, 8.8e-29
• PF00501: AMP-binding
  • amino acids 67 to 443 (377 residues), 256.9 bits, E=4.4e-80
• PF13193: AMP-binding_C
  • amino acids 511 to 594 (84 residues), 94.7 bits, E=7.7e-31

Best Hits

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 95% identity to bug:BC1001_2443)

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
• 2-methylcitrate cycle I (5/5 steps found)
• β-alanine biosynthesis II (5/6 steps found)
• 2-methylcitrate cycle II (5/6 steps found)
• acrylate degradation II (2/3 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Protein Sequence (630 amino acids)

>ABIE53_002938 propionyl-CoA synthetase (Paraburkholderia graminis OAS925)
MTRYRDFHRRSIDNPEAFWRDEARRIHWETPFDTVLDRSNPPFARWFVGGRTNLCHNAVD
RHLVERAQQNALVYVSTETGIERRYTYAELYAEINRMAAVMRSLGVKRGDVVLLYLPMIP
EALFAMLACARLGAIHSVVFGGFAAPNLAARIDDAKPVLIVTADAGARGGRVIDYTPLVD
EALARASHKTPRVLLIDRQLAPERLNANYLVDYEPLREKFFDAHVPCEWLESNEPSYVLY
TSGTTGKPKGVQRDVGGYAVALAASMEHIFEGKAGDTMFTASDVGWVVGHSYIVYAPLLA
GLTTVMYEGTPIRPDGGIWWRLVEQHKINLMFTAPTALRVLKKQDPALLKQADLSSLRTL
FLAGEPLDEPTASWIAGALGKPVIDNYWQTETGWPMLAIPRGVEALPTKLGSPGVPSAGF
SLTLRNELTGEPCPPGEKGVLTLDYPLPPGCMSTVWGDDKRFVSTYWSSVPNQQVYSTFD
WGIQDEDGYVTILGRTDDVINVAGHRLGTREIEEALSSHPAVAEVAVVGVTDAVKGQAAM
AFVVLRDAQAYADAGTRTKLEAELTTTVDRQLGAIARPSRVVIVSMLPKTRSGKLLRRAI
AALAEGREPGELPTIEDPAALQQVREGLKG