Protein Info for ABIE53_002937 in Paraburkholderia graminis OAS925

Annotation: adenosylhomocysteine nucleosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01048: PNP_UDP_1
  • amino acids 35 to 278 (244 residues), 173.9 bits, E=1.8e-55
• TIGR01704: MTA/SAH nucleosidase
  • amino acids 59 to 272 (214 residues), 113.9 bits, E=4.2e-37

Best Hits

KEGG orthology group: K01243, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase [EC: 3.2.2.9] (inferred from 88% identity to bgf:BC1003_2413)

Predicted SEED Role

"5'-methylthioadenosine nucleosidase (EC 3.2.2.16) @ S-adenosylhomocysteine nucleosidase (EC 3.2.2.9)" (EC 3.2.2.16, EC 3.2.2.9)

MetaCyc Pathways

• 5'-deoxyadenosine degradation II (4/4 steps found)
• S-methyl-5'-thioadenosine degradation I (2/2 steps found)
• S-methyl-5'-thioadenosine degradation IV (1/1 steps found)
• autoinducer AI-2 biosynthesis II (Vibrio) (4/6 steps found)
• autoinducer AI-2 biosynthesis I (3/5 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (3/7 steps found)
• L-methionine salvage cycle I (bacteria and plants) (5/12 steps found)
• L-methionine salvage cycle II (plants) (4/11 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.16 or 3.2.2.9

Protein Sequence (283 amino acids)

>ABIE53_002937 adenosylhomocysteine nucleosidase (Paraburkholderia graminis OAS925)
MSGVDGGERTAQAGGPLDDPQGANAQVTHLARRPLGVLAALPQELGDLIEGMRAESGVRT
VIHGRRDYHVGTVHGVPCVVTLARVGKVAAAATVSALIHAFDVEAVVFTGVAGGVGEQVR
VGDIVVANALLQHDLDASPLFPRFEVPLLGMSRFAADAALAAQLAQACERFIADEGAASA
ARFGTREARVHRGLIVSGDQFVASAAGVRALRDALPDALAVEMEGAAIAQVCHEYGVPCA
VVRTISDTADDHAPASFVSFLTEIAGTYSNAILTRFLKARGEA