Protein Info for ABIE53_002821 in Paraburkholderia graminis OAS925

Annotation: diguanylate cyclase (GGDEF)-like protein/PAS domain S-box-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 765 PF13185: GAF_2" amino acids 43 to 188 (146 residues), 68.1 bits, see alignment E=2.4e-22 PF01590: GAF" amino acids 45 to 187 (143 residues), 55.9 bits, see alignment E=1.7e-18 TIGR00229: PAS domain S-box protein" amino acids 198 to 329 (132 residues), 25 bits, see alignment E=1.8e-09 PF00989: PAS" amino acids 202 to 306 (105 residues), 23.5 bits, see alignment E=1.2e-08 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 329 to 496 (168 residues), 136.5 bits, see alignment E=7.2e-44 PF00990: GGDEF" amino acids 333 to 494 (162 residues), 150.9 bits, see alignment E=6.8e-48 PF00563: EAL" amino acids 514 to 748 (235 residues), 256 bits, see alignment E=8.1e-80

Best Hits

KEGG orthology group: None (inferred from 94% identity to bug:BC1001_2335)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (765 amino acids)

>ABIE53_002821 diguanylate cyclase (GGDEF)-like protein/PAS domain S-box-containing protein (Paraburkholderia graminis OAS925)
MNREATSRMEAGATPDSCRYRPDLAEEVLASERSVLRLITRNTPLPELLDEVCHRAEALL
GSGAACSILLLDEDGLHVRMGGAPSLPAHFSAAIDGVAIGPCAGSCGTAMYERRLVVVED
IETDPLWADFRALALPLGLRACWSVPFENDAGAVLGAFAVYHREPRRPTAQEETMLRDIG
RSVGLAVHQDAMAQRLANSEEHHRLVVDHLIEGIVVQSREGVVLACNPSAQRMLRTGPQI
VGRSIRTVMVRGFHEDGSPVKEDERPTSQVLATGKPMLGVTLAVELVSGEVIWITENVVP
ILKPGQSKPDSVLISFTDIGPVREAQRQLKFLATRDSLTGLYNRAYLTERMNSLFAPGAP
NGSGEFANVAVLFVDLDGFKKVNDTAGHEAGDALLKSVAQRLAGCVGPDDTLARVGGDEF
VIVVGASDCSDRLIALARHILDEIAVPFAVADNEYYLGASIGISRFPEDGQDAPTLMRNA
DSAMYHAKQRGRNNFQFFTAELNQQLQRRFVIEQSLRRALAGGELSLVYQPIVDSHAGRT
IGAEALLRWYNSELGNVSPAEFIPVAEDAGLIAEIGEWVLAHACEQAARWRRTLAPDLIV
AVNLSPRQFNDGLVERIRRCLDQSGLDPAALELEITERLLMSDSDTVLPMLQTLSATGVR
ISVDDFGTGYSSLSYLKRFPLHNLKIDRSFVAGLPDHRDSIAITQAVVAMAHSLGMNVTA
EGVETPEQAAFLRSIDCDKQQGYLYSRPVGASAYARALADAYAAT