Protein Info for ABIE53_002496 in Paraburkholderia graminis OAS925

Annotation: regulator of sigma E protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 467 transmembrane" amino acids 7 to 24 (18 residues), see Phobius details amino acids 101 to 124 (24 residues), see Phobius details amino acids 392 to 414 (23 residues), see Phobius details amino acids 440 to 461 (22 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 2 to 465 (464 residues), 325.9 bits, see alignment E=1.9e-101 PF02163: Peptidase_M50" amino acids 9 to 452 (444 residues), 237.1 bits, see alignment E=3.1e-74 PF00595: PDZ" amino acids 220 to 282 (63 residues), 29.5 bits, see alignment E=1.5e-10 PF13180: PDZ_2" amino acids 224 to 286 (63 residues), 29.1 bits, see alignment E=2.1e-10 PF17820: PDZ_6" amino acids 232 to 284 (53 residues), 52 bits, see alignment 9.7e-18

Best Hits

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 95% identity to bug:BC1001_2157)

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (467 amino acids)

>ABIE53_002496 regulator of sigma E protease (Paraburkholderia graminis OAS925)
MNLLIEVLAFAVAIGVLVVVHEYGHYSVARLCGVKVLRFSIGFGKPLFQWVSPKSGTEWT
VAALPLGGYVKMLDERETGGAPIPAEALPHAFNRQSVWRRIAIVAAGPVANFLLAIVLFG
LVFATGVTEPAAILATPAPNTTAAAAGFEGGETVVAVRAENAADSEPVRSWSDLRWKLLG
AAFDHKRVVLIAKGANGPSDFQLDLRGVTEKDVDDDFMSRLGFEPGGGKLTVAGVQPGSA
AQKAGLLPGDRLRAINGVATDNATAFIAYVKSHAGQPLTLQVERAAAGQTEAQGSGKLED
IRIVPQAQRDAATGQQVGRIGAELATQVPSINVRYGPVESLQLGARRTWDLAVYSVRMFG
RMIVGDASLKNLSGPVTIADYAGKSARLGPSAFLSFLALVSISLGVLNLLPIPVLDGGHL
LYYLVEAVTGKVVSDRWQLVFQRAGLACIVALSAIALFNDLARLIHF