Protein Info for ABIE53_002274 in Paraburkholderia graminis OAS925

Annotation: 2-aminoethylphosphonate-pyruvate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 TIGR02326: 2-aminoethylphosphonate--pyruvate transaminase" amino acids 25 to 386 (362 residues), 485.8 bits, see alignment E=8.5e-150 TIGR03301: 2-aminoethylphosphonate aminotransferase" amino acids 27 to 383 (357 residues), 475 bits, see alignment E=1.8e-146 PF00266: Aminotran_5" amino acids 144 to 328 (185 residues), 49.4 bits, see alignment E=1.8e-17

Best Hits

Swiss-Prot: 87% identical to PHNW1_PARXL: 2-aminoethylphosphonate--pyruvate transaminase 1 (phnW1) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K03430, 2-aminoethylphosphonate-pyruvate transaminase [EC: 2.6.1.37] (inferred from 88% identity to bug:BC1001_1572)

MetaCyc: 52% identical to 2-aminoethylphosphonate aminotransferase monomer (Pseudomonas aeruginosa)
2-aminoethylphosphonate--pyruvate transaminase. [EC: 2.6.1.37]

Predicted SEED Role

"2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37)" in subsystem Phosphonate metabolism (EC 2.6.1.37)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.37

Use Curated BLAST to search for 2.6.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>ABIE53_002274 2-aminoethylphosphonate-pyruvate transaminase (Paraburkholderia graminis OAS925)
MQNATGNSPATAQESASCAPPAQGEPYLLTPGPLTTAFSTKQAMLRDWGSWDGDFRAMTA
QLRRSLLDIAGDASDDAGEYDCVPLQGSGSYCVEAMLGSLIPRDGNALVLANGAYGKRIA
TTLRYLGRAHTVLDKGDYLPPRATEVERMLDAEPAITHVVAVHCETSSGILNPIEEIAAV
TAAKGRKLLIDSMSAFGAVPLDVRKIACEAFVSSANKCIEGVPGFGFVIAKKSALHDARG
RSHSLALDVHDQWDVMNRTGQWRFTPPTHTVAAFIEALRLHKLEGGQPARLARYANNRDV
LVAGMQELGFEPLLNARWRSPIIVTFFSPAHPAFSFEQFYELMKQQGFIIYPGKLTVVES
FRIGCIGQVDAQVMRRVVQACASALRTMGVDHAAPPAAAIEERKLLAELA