Protein Info for ABIE53_001556 in Paraburkholderia graminis OAS925

Annotation: two-component system sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 962 transmembrane" amino acids 412 to 430 (19 residues), see Phobius details amino acids 436 to 452 (17 residues), see Phobius details amino acids 459 to 476 (18 residues), see Phobius details amino acids 488 to 509 (22 residues), see Phobius details PF02702: KdpD" amino acids 21 to 230 (210 residues), 327.7 bits, see alignment E=7.9e-102 PF13493: DUF4118" amino acids 413 to 519 (107 residues), 111.3 bits, see alignment E=5.8e-36 PF13492: GAF_3" amino acids 540 to 661 (122 residues), 55.2 bits, see alignment E=2.9e-18 PF00512: HisKA" amino acids 681 to 749 (69 residues), 57.9 bits, see alignment 2.6e-19 PF02518: HATPase_c" amino acids 794 to 917 (124 residues), 79.4 bits, see alignment E=8.4e-26

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 90% identity to bug:BC1001_1050)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (962 amino acids)

>ABIE53_001556 two-component system sensor histidine kinase KdpD (Paraburkholderia graminis OAS925)
MNRPDPDELLDKLQRDEQKRQRGKLKIFFGASAGVGKTYAMLQAARRRRDEGADVVVGIA
ETHGRGETAALLEGLDVLPLAHIEYRGRKLGEFDLDAALARKPQLILVDELAHSNVQGAR
HLKRWQDVYELLDAGIDVYTTVNVQHLESLNDVVGQITGIRVWETVPDRVFDRADEVTLV
DLPAEELLDRMRDGKVYLAQQAERAVRNFFRKGNLIALRELALRRTADRVDAQMREYRAD
RSIERIWQARERLLVCVGPGPEAPMLVRAAARLAASLKADWIAVYVETPALQRLPDARRE
RTLNALKLAAELGAETATLAGADAVAALTGYAQARNVSKLVAGASARTGIRRWLRRPLGE
RLAEHGGHADVTLIRASSDSGGDHERRLLSTTANAWRDALSAARERRSPPRAYGWALAIC
AGITAVASQLNERIDLTNLVMLYLLGVIFAAVKLGRGPGVLLSFMSVAAFDFFFVPPRLS
LSVSDTQYLLTFFGMLLTSLVISHLTSSLRREARIARRREQRTGAMYAMARELAAALTTE
QIVGIGSRHVSEVFGARVAILLPDSADRVKQKIEDPDAAITLEGELLDTDVGQWVYDHEK
PAGHGTDTLPAAAALYLPLKAPMRTRGVLAAVLRDERELNAPEQQRMLDAFAAQIALALE
RVHYVDIARDALVNMESERLRNSLLSAISHDLRTPLTTIVGFSSMLAQSREHAADARRDD
ELVDAIHEEALRMTGIVTNLLDMARLQAGSLQLNRQWTLLEETVGAALRACKRVLSGHPV
RVELAADLPLLQLDAVLMERLFSNLFENAAKYTSTGTPLTIGAQRFDADGKSFVRVTIDD
NGPGLPAGMETRVFEKFTRGEKESAKPGIGLGLAICRAIVEAHGGSIGAVNRMSAATDEA
ARSRVEGARFWFTLPVETPPDVPDLPEAADAPDAPDALQDQSAEDQSADNMNPNPLAKPT
HE