Protein Info for ABIE53_000915 in Paraburkholderia graminis OAS925

Annotation: xanthine dehydrogenase small subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02963: xanthine dehydrogenase, small subunit
  • amino acids 5 to 482 (478 residues), 702.1 bits, E=1.5e-215
• PF00111: Fer2
  • amino acids 17 to 57 (41 residues), 22.1 bits, 2.4e-08
• PF01799: Fer2_2
  • amino acids 85 to 167 (83 residues), 101 bits, E=6.5e-33
• PF00941: FAD_binding_5
  • amino acids 207 to 370 (164 residues), 166.7 bits, E=9e-53
• PF03450: CO_deh_flav_C
  • amino acids 381 to 481 (101 residues), 103.8 bits, E=1e-33

Best Hits

KEGG orthology group: K13481, xanthine dehydrogenase small subunit [EC: 1.17.1.4] (inferred from 94% identity to bxe:Bxe_A3886)

Predicted SEED Role

"Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A (1.17.1.4)" in subsystem Purine Utilization

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (521 amino acids)

>ABIE53_000915 xanthine dehydrogenase small subunit (Paraburkholderia graminis OAS925)
MTEPIRFYHRNAIREIKDAPVTRTVLQYLREDVHCTGTKEGCAEGDCGACTVVIGERNEA
GGVDFKTVNACIQFMPTLDGKALFTVEDLRQPDGSLHPVQEAMVECHGSQCGFCTPGFVM
SMWSLYEKHGHEHSCANRTVPSRETISNALTGNLCRCTGYRPIVDAAVRMFEAPAPKAPV
NVDALARSLATLQRDDTFHYEHAGQRFHAPRTVEALAQIKEAEPAARILAGSTDIGLWVT
KQMRELGNVVYVGQIAELQKLETRGEWIEIGAGVTVEKAYAEIAKQYPELTEMWQRFASL
PIRNAGTLGGNIANGSPIGDSMPGLIALGARVIVRGGAIEREMRLEDLYLAYQKKDMAEH
EFVVSVKVPTRTGVREKLQFRTYKLSKRFDSDISAVCAAFSFIADGKLIREPRIAFGGMA
ATPKRATHAEAVLRDAEWHEATAQAAMLALGNDYAPLSDMRATSNYRLEAAKNTLYRFWL
ETRPHNPLPKNALDVRAVEAACAPAGVDVDIGGQLNAAASA