Protein Info for ABIE53_000904 in Paraburkholderia graminis OAS925

Annotation: fumarylacetoacetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 TIGR01266: fumarylacetoacetase" amino acids 17 to 435 (419 residues), 607.8 bits, see alignment E=4.9e-187 PF09298: FAA_hydrolase_N" amino acids 32 to 138 (107 residues), 107.9 bits, see alignment E=2.9e-35 PF01557: FAA_hydrolase" amino acids 145 to 413 (269 residues), 122.6 bits, see alignment E=2e-39

Best Hits

Swiss-Prot: 59% identical to FAAA_HUMAN: Fumarylacetoacetase (FAH) from Homo sapiens

KEGG orthology group: K01555, fumarylacetoacetase [EC: 3.7.1.2] (inferred from 92% identity to bug:BC1001_0490)

MetaCyc: 59% identical to Fumarylacetoacetase (Homo sapiens)
Fumarylacetoacetase. [EC: 3.7.1.2]

Predicted SEED Role

"Fumarylacetoacetase (EC 3.7.1.2)" in subsystem Homogentisate pathway of aromatic compound degradation or Salicylate and gentisate catabolism (EC 3.7.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.7.1.2

Use Curated BLAST to search for 3.7.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>ABIE53_000904 fumarylacetoacetase (Paraburkholderia graminis OAS925)
MSAVSDLQATLDPSRKSWVESANEPSHDFSIQNLPFGIFSDTANDTSNDTRRAGVAIGDE
IVDLAALQAAGLLKLPSNADVFARDTLNDFIALGRDAWRSVRIQLSNLLSRDTATLRDDA
ALRAKVLVRAADARLHLPVEIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYN
GRASSVVVSGTPVRRPNGQLKLPDQDRPVFGACRKLDIELETGFVIGGGNALGEPIACAD
AEAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPVQE
PEPLAYLRHDGDHAFDIALEVKLRPHAAKQATTIARTNFRHMYWTMAQQLAHHTVSGCNT
RVGDLMGSGTISGPTEDSYGSLLELTWNGKKPLELKDGGTRTFIEDGDELTLAGWCQGDG
YRVGFGACVGEIVAARG