Protein Info for ABIE53_000845 in Paraburkholderia graminis OAS925

Annotation: D-lactate dehydrogenase (cytochrome)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 471 PF01565: FAD_binding_4" amino acids 52 to 189 (138 residues), 144.8 bits, see alignment E=1.4e-46 PF02913: FAD-oxidase_C" amino acids 226 to 466 (241 residues), 222.6 bits, see alignment E=6.8e-70

Best Hits

Swiss-Prot: 54% identical to LDHD_MOUSE: Probable D-lactate dehydrogenase, mitochondrial (Ldhd) from Mus musculus

KEGG orthology group: None (inferred from 98% identity to bug:BC1001_0434)

Predicted SEED Role

"D-Lactate dehydrogenase, cytochrome c-dependent (EC 1.1.2.4)" in subsystem Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 1.1.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (471 amino acids)

>ABIE53_000845 D-lactate dehydrogenase (cytochrome) (Paraburkholderia graminis OAS925)
MNYGVPPAALRRPFPPELLNALTDAFGERVSVAQAVREHHGRDESPFDPQLPDAVVFARN
TEDVQTIVKLCGQYNVPIIPYGNGSSLEGHLLAVQGGVSIDLSEMNRVLSINAEDLTVTV
EPGISRKQLNEALRDTGLFFPIDPGADASIGGMSATRASGTNAVRYGTMRENVLGLTVVL
ADGRVIKTGTRARKSSAGYDLTRLFVGSEGTLGVITEITVRLYPQPEAVSAAVCAFPSMG
DAVRAVIETIQMGVPIARVEFVDALAIRSINRHSNLTLREAPTLFFEFHGTEAGVKEQAE
LVQELAAQNGGEGFEWATRPEDRSRLWNARHNAYFAMLQLKPGCRAVTTDVCVPISRLAE
CVVETEQDLKTSPLPCPIVGHVGDGNFHVAILIDPNKPEELVEAERLNHRIVQRALRMDG
TCTGEHGVGLHKMNFLLEEHGDVAIDTMRSIKHALDPHNLMNPGKIFSWAA