Protein Info for ABIE53_000725 in Paraburkholderia graminis OAS925

Annotation: adenine phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01090: adenine phosphoribosyltransferase
  • amino acids 16 to 181 (166 residues), 210.5 bits, E=8.9e-67
• PF00156: Pribosyltran
  • amino acids 39 to 164 (126 residues), 48.3 bits, E=3.7e-17

Best Hits

Swiss-Prot: 93% identical to APT_PARPJ: Adenine phosphoribosyltransferase (apt) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K00759, adenine phosphoribosyltransferase [EC: 2.4.2.7] (inferred from 96% identity to bug:BC1001_0318)

MetaCyc: 47% identical to adenine phosphoribosyltransferase (Escherichia coli K-12 substr. MG1655)
Adenine phosphoribosyltransferase. [EC: 2.4.2.7]

Predicted SEED Role

"Adenine phosphoribosyltransferase (EC 2.4.2.7)" in subsystem Purine conversions or cAMP signaling in bacteria (EC 2.4.2.7)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (12/14 steps found)
• adenine salvage (3/3 steps found)
• adenine and adenosine salvage II (2/2 steps found)
• guanine and guanosine salvage II (2/2 steps found)
• adenine and adenosine salvage I (1/2 steps found)
• guanine and guanosine salvage I (1/2 steps found)
• superpathway of guanine and guanosine salvage (1/3 steps found)
• glyphosate degradation III (3/7 steps found)
• (aminomethyl)phosphonate degradation (3/8 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.7

Protein Sequence (188 amino acids)

>ABIE53_000725 adenine phosphoribosyltransferase (Paraburkholderia graminis OAS925)
MSNALASAPLDAADYIKSHIRTVQDWPQAGVQFRDITPLLREPRSLRVLIDLFVQRYIDA
KLDYIAGLDARGFIIGPILAYELNLGFIPIRKEGKLPYKRASQSYELEYGTATVEIHEDA
CKPGDRVLIVDDLIATGGTMMAGKILLERLGAVVVEGAAIIDLPELGGSKLLAGGGLPLY
TVTSFDGH