Protein Info for ABIE53_000564 in Paraburkholderia graminis OAS925

Annotation: methylmalonyl-CoA mutase cobalamin-binding domain/chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00641: methylmalonyl-CoA mutase N-terminal domain
  • amino acids 159 to 704 (546 residues), 380.7 bits, E=4.4e-118
• PF01642: MM_CoA_mutase
  • amino acids 181 to 698 (518 residues), 407.9 bits, E=3.1e-126

Predicted SEED Role

"B12 binding domain / kinase domain / Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• propanoyl CoA degradation I (2/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (12/17 steps found)
• 2-oxobutanoate degradation I (2/4 steps found)
• conversion of succinate to propanoate (1/3 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• pyruvate fermentation to propanoate I (3/7 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• methylaspartate cycle (11/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (5/13 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• L-glutamate degradation VIII (to propanoate) (3/11 steps found)
• superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (2/14 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 5.4.99.2

Use Curated BLAST to search for 5.4.99.2

Protein Sequence (705 amino acids)

>ABIE53_000564 methylmalonyl-CoA mutase cobalamin-binding domain/chain (Paraburkholderia graminis OAS925)
MTALYVHLANALHKHGLRADGGGRLAARADLRFSSGRHAIVPPARVRYLAEIAQTVHVYR
ERADAQARIARERWQLIEARRMLGEADTNDNDTNNDTNANAPTAQLDALIEQRTAALGEH
ERKLLDAWPQTVAAYSGDEHVIRIRDREIRTALTVTTLSGTPIRKVALPKFVDHGEILRW
LMLENLPGYFPFAAGVFPFRRENEDPTRMFAGEGDPSRTSRRFKLLSEGMPAKRLSTAFD
SVTLYGEEPHERPDIYGKVGNSGVSVATLDDMHALYDGFDLCAPETSVSMTINGPAPTIL
AMFFNVAIYQQITRKQHELGRALTDDELAATRHIALENVRGTVQADILKEDQGQNTCIFS
TEFSLKVMGDIQAYFVEHGVRNFYSVSISGYHIAEAGANPISQLAYTLANGFTYVEAYLA
RGMSIDDFAPNLSFFFSNGMDPEYTVLGRVARRIWAIAMRERYGANERSQKLKYHVQTSG
RSLHAQEIDFNDIRTTLQALIAIYDNCNSLHTNAFDEAITTPTEESVRRAVAIQLIINRE
WGLAKNQNPNQGSFVIDELTDLVEEAVLAEFDRLTERGGVLGAMETGYQRGRIQDESMLY
EHRKHDGSYPIVGVNTFVSAHPHEAPQPIALARSTDEEKQSQLKRLRDFQARHREAAPAA
LERLKRAVIDDENVFAVLMDVVRVCSLGQITHALFEVGGQYRRNM