Protein Info for ABIE53_000238 in Paraburkholderia graminis OAS925

Annotation: glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 978 transmembrane" amino acids 344 to 364 (21 residues), see Phobius details PF02347: GDC-P" amino acids 28 to 454 (427 residues), 598.2 bits, see alignment E=1.4e-183 amino acids 480 to 756 (277 residues), 42.2 bits, see alignment E=7.8e-15 TIGR00461: glycine dehydrogenase" amino acids 29 to 971 (943 residues), 1475.3 bits, see alignment E=0 PF00266: Aminotran_5" amino acids 599 to 726 (128 residues), 22 bits, see alignment E=1.1e-08 PF21478: GcvP2_C" amino acids 799 to 920 (122 residues), 201 bits, see alignment E=6.8e-64

Best Hits

Swiss-Prot: 59% identical to GCSP1_COLP3: Glycine dehydrogenase (decarboxylating) 1 (gcvP1) from Colwellia psychrerythraea (strain 34H / ATCC BAA-681)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (978 amino acids)

>ABIE53_000238 glycine dehydrogenase (Paraburkholderia graminis OAS925)
MKLEHPDRLMNRTPLSLAALEVHDAFAERHIGPDAADQQAMLEALGFASRAALIDAVIPK
TIRRTEPLPLGPFTQPKSEAEALAALRELADKNQVFRSYIGQGYYNAHTPTVILRNVLEN
PAWYTAYTPYQPEISQGRLEALLNFQQMVIDLTGLAISNASLLDEATAAAEAMTLLQRVG
KPKSNVFYVADDVLPQTVEVIKTRATPVGIEVKVGPADEAANANAFGVLLQYPGVNGDVR
DYRALTEAIHAAGGHVVVAADLLALTVLTPPGEWGADVAVGNTQRFGVPVGFGGPHAAYL
AVRDEFKRQMPGRLVGVTVDAQGNPALRLALQTREQHIRREKATSNVCTAQALLAIMASM
YAVYHGPRGLKTIALRVNRIAALLAEGAKQLGYTLVNETFFDTLTFDAGARTQALHDAAN
AKRINLRRVSGTQVGVSIDETTTRADLADLLAVFAQAAGARDVPQVDALDSALTASNTAS
VPASLERTSAYLTHHVFNRHHSETEMLRYLRSLSDKDLALDRSMIPLGSCTMKLNATSEM
LPVTWPEFGQIHPFAPAEQTVGYREMIDQLEAMLVAATGYAAVSLQPNAGSQGEYAGLLI
IHAYHASRGEAHRNVCLIPASAHGTNPASAQMAGMQVVVVACDAQGNVDIEDLKKKADQH
ADKLAAIMITYPSTHGVFEANVREICEIVHARGGQVYVDGANMNAMVGLTAPGQFGGDVS
HLNLHKTFCIPHGGGGPGVGPVAVGAHLAQFLPNQISSGYERAPNGIGAVSGAPYGSASI
LPISWMYIAMMGAKNLTAATETAILNANYVAKKLAPHYPVLYSGPGGLVAHECILDLRPI
KETSGITVDDVAKRLADYGFHAPTMSFPVPGTLMVEPTESESKEELDRFIEAMIAIREEI
RAVEEGHSDREDNPLKHAPHTAAVVIADDWKHTYARETAAYPLPTLIAKKYWPPVGRADN
VYGDRNLFCSCVPVADYE