Protein Info for ABIE51_RS18320 in Lysobacter sp. OAE881

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 610 (609 residues), 861.8 bits, E=1.4e-263
• PF13522: GATase_6
  • amino acids 64 to 181 (118 residues), 74 bits, E=1.8e-24
• PF13537: GATase_7
  • amino acids 81 to 198 (118 residues), 57.1 bits, E=2.7e-19
• PF01380: SIS
  • amino acids 291 to 417 (127 residues), 98.4 bits, E=4.3e-32
  • amino acids 464 to 592 (129 residues), 85.5 bits, E=4.3e-28

Best Hits

Swiss-Prot: 82% identical to GLMS_XANCP: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 82% identity to psu:Psesu_2488)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.16

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (610 amino acids)

>ABIE51_RS18320 glutamine--fructose-6-phosphate transaminase (isomerizing) (Lysobacter sp. OAE881)
MCGIVGAIADRDVVPVLIEGLKRLEYRGYDSAGIAVLDGEQVRRVRRTGRVSEMETAAQS
EGFHARLGIGHTRWATHGGVTEANAHPHVSFGELAVVHNGIIENHDEQREALRARGYVFE
SQTDTEVIAHLIHFHQSQGADLLAAVQKAVHELVGAYAIAVVSKREPGRLIAARMGCPLL
VGLGEGENFIASDVSAILQATRQVIFLEEGDTAEVTRESVRVFDASGAAIEREVHVSDVS
LASLELGPYRHFMQKEIHEQPRAIADTIEAVMDANAFNALLFGADAEHVLRDVEGVQILA
CGTSYYAGLTARYWIEAISGLPCSVEIASEYRYRKAVANPKHLIVTISQSGETLDTMEAL
KYAKSLGHDRTLSICNVPESAIPRASRLVYYTRAGAEIGVASTKAFTTQLVALFTLAATL
AKLQNRLSVEQEGQYLDALRFLPGSVQHALNLEPQVTAWAERFAPKQHALFLGRGVHYPI
ALEGALKLKEISYIHAEAYPAGELKHGPLALVDAAMPVVVIAPNDTLLEKVKSNMQEVRA
RGGELFVFTDEDSQFGPSEGVHVIRAPRHVGVLSPVVHAIPVQLLAYHAALARGTDVDKP
RNLAKSVTVE