Protein Info for ABIE51_RS18005 in Lysobacter sp. OAE881

Annotation: TonB-dependent vitamin B12 receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details TIGR01779: TonB-dependent vitamin B12 receptor" amino acids 10 to 619 (610 residues), 650.4 bits, see alignment E=1.5e-199 PF07715: Plug" amino acids 47 to 152 (106 residues), 97.1 bits, see alignment E=8.7e-32 PF00593: TonB_dep_Rec" amino acids 281 to 594 (314 residues), 157.2 bits, see alignment E=1.3e-49

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 51% identity to psu:Psesu_2475)

Predicted SEED Role

"Outer membrane vitamin B12 receptor BtuB" in subsystem Coenzyme B12 biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>ABIE51_RS18005 TonB-dependent vitamin B12 receptor (Lysobacter sp. OAE881)
MSFRSLHVQALALACASALPLLAHAAPQATDLDEVVVTANRTAVTVNDALAPVEVIDAEQ
IRRSQARSLPDLLRGRAGISLSNQGGAGKLTTLFLRGAESDHVLVLVDGIRIGSATSGLA
SLQDLPVDLIDRVEIVRGPRSSLYGADAIGGVIQVFTRRDREGFAPRVTVGGGSNGLNEF
ATGFGGRSGRTWFGADYSHSHTQGINACRGYFDPVTFDGAGCFIAPDSQPDRDGYTRDAL
SVRGGIEFNEQWSLEGHGLRNEGDNEFDGDFTDRAKTVQQVVGGKLRWHPNDRVDLHLTA
GRNTDASDNYLGDTYLDYFSTYRDSATLQGDFGLAEKHLLSVGLDWLDDSVSSTTEYDEL
SRDNKAAFVQYQGRIGAQSLEASVRRDDNEQFGGHTTGSAAWGIEFAQNWRVTAGYGSAF
KAPTFNELYYPFFGNANLRPEDSETWELGVAWRGETFNVRLDTFDTDVDDLIAFDAAIGL
PNNVERARMRGAELGVDTTVAEWTINGAISYLDTENRSGFYEGNDLARRAKNSARVDVDR
AFGKFRIGATAVGEGSRFDDVANTRRLGGYGTLDLRAEYAITSSLTLQARVANVFDRDYE
TVAFYNQGGREWFLTLRYAPVN