Protein Info for ABIE51_RS17530 in Lysobacter sp. OAE881

Annotation: threonine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 2 to 75 (74 residues), 52.8 bits, E=3.7e-18
• TIGR00260: threonine synthase
  • amino acids 74 to 394 (321 residues), 245.1 bits, E=5.8e-77
• PF00291: PALP
  • amino acids 93 to 378 (286 residues), 100.1 bits, E=1.6e-32

Best Hits

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 62% identity to smt:Smal_1751)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
• aspartate superpathway (19/25 steps found)
• L-threonine biosynthesis (2/2 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (11/15 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.3.1

Use Curated BLAST to search for 4.2.3.1

Protein Sequence (439 amino acids)

>ABIE51_RS17530 threonine synthase (Lysobacter sp. OAE881)
MKFVSTRGNTPPTQIDAALVAGLAPDGGLYVPERIPTVDIEPGDTLAQTAQTVLSPYFVE
SSLRDALPAICAHAYSFDAPLRAMTGNGDHLLELFHGPTAAFKDYAARFLAEALSRLRPS
DAAPTTIVVATSGDTGAAVASAFHRRDGFNVVILYPEGRVSPRQAHGLECWGDNVRTFRV
QGTFDDCQRMAKQALSDEALRREVSLSSANSISLGRLLPQVAYYAHAALHFARRHGEALN
LIVPTGNLGNACAAFVARRMGLPIGDLVLACNANDVLPRYFAGDPYEPRATKATLANAMD
VGAPSNFERLRHWHADDDELRGSLRAFTVDDATITDVVREAPRRHGVVADPHTAAGLHVL
ETFRSQGDSRPWAVVATAHPAKFDTIVEPLVGHEVPVPPSLAQCLARPASAQRLPADYAA
LRDALRTGAVTSETIGRSA